A new animal model of traumatic brain injuries can help scientists test treatments and understand long-lasting effects
UCLA discovers first stroke rehabilitation drug to repair brain damage
A new study by UCLA Health has discovered what researchers say is the first drug to fully reproduce the effects of physical stroke rehabilitation in model mice.
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. This study aimed at investigating the potential regulatory capacity of the potent synthetic cannabinoid HU210 on hippocampal neurogenesis and its possible correlation with behavioral change. We show that both embryonic and adult rat hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids could act on CB1 receptors to regulate neurogenesis. This hypothesis is supported by further findings that HU210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal NS/PCs likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. Chronic, but not acute, HU210 treatment promoted neurogenesis in the hippocampal dentate gyrus of adult rats and exerted anxiolytic- and antidepressant-like effects. X-irradiation of the hippocampus blocked both the neurogenic and behavioral effects of chronic HU210 treatment, suggesting that chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis.
People With Brain Injuries Heal Faster If They Get Up And Get Moving
Doctors tell surgical patients to get out of bed as soon as possible, but people with brain injuries are encouraged to rest. Now it looks like activity can benefit brain injured patients, too.
What stress does to the brain - Neuroscience News
A new study sheds light on how the brain changes as a result of chronic stress. Selective noradrenaline release rewires connectivity patterns between different brain regions. Activity in the amygdala and networks that process sensory stimuli increased.
Football headers 'linked to brain damage'
Footballers suffer similar brain damage to boxers, a small scientific study suggests.
The New Wounded
This book addresses the issue of trauma and psychic wounds to stage a confrontation between psychoanalysis and contemporary neurobiology. In so doing, it reevaluates the brain as an organ that is not separated from psychic life but rather appears as its very locus. A philosophical approach of the “new wounded” (brain lesion patients) forms the matter of the confrontation.
Leading Innovation in Psychiatric Treatment | Alto Neuroscience
We leverage brain biology to develop personalized medicines, helping patients get better faster.
Which Type of Exercise Is Best for the Brain?
For the first time, scientists compared the neurological impacts of different types of exercise in rats: running, weight training and high-intensity interval training.
The medications that change who we are
They’ve been linked to road rage, pathological gambling, and complicated acts of fraud. It turns out many ordinary medications don’t just affect our bodies – they affect our brains.
FDA Designates MDMA As 'Breakthrough Therapy' For Post-Traumatic Stress
The drug, often used recreationally in the form of ecstasy, has been found to offer a potentially significant advantage over extant treatments for the disorder.
Learning What Substance Is Suspected of Causing Alzheimer’s May Throw You Into an Existential Crisis
A surprisingly common substance was found to have a causal relationship with the kind of brain damage associated with Alzheimer's disease.
Arbor Neuroscience
Arbor Neuroscience is building the instruments, data, and models to make neuromodulation predictable – brain-circuit treatment targeted to the individual patient.
From treating PTSD to quitting tobacco: researchers say public investment into psychedelic drugs essential | CBC News
Magic mushrooms to treat depression, ecstasy to cure PTSD and LSD to combat alcoholism; just some of the drug-affliction pairings that have been tested in recent years.
Chronic methylphenidate abuse: Effects on behaviour, redox homeostasis, and cholinergic system
Methylphenidate (MPH) (metil 2-fenil-2-(piperidin-2-il) acetato) is used as a drug of abuse as well as a cognitive enhancer owing to its amphetaminic structure. The objective of this study was to evaluate whether chronic exposure to an abusive context and dose of MPH (80 mg/L for 15 min/day for 7 days) in adult life causes behavioural changes related to anxiety, fear, sociability, locomotion, and memory as well as altered levels of biochemical markers, cortisol, and the cholinergic system. Here we used the zebrafish (Danio rerio) as a translatio Nnal model. We showed that fish exposed to MPH showed marked hypolocomotion and anxiogenic patterns, fear behaviour, and memory delay. MPH exposure also increased the levels of antioxidant enzymes, non-protein thiols, and reactive oxygen species compared with those in the control group, and the redox status was altered at the cerebral and peripheral levels. The cholinergic system exhibits a reduction in signalling and an increase in cortisol levels. Our results clarified the mechanisms involved in the toxicity elicited by the abusive use of MPH. Overall, our results demonstrated that chronic administration of an abusive dose of MPH in individuals without a diagnosis of attention deficit hyperactivity disorder (ADHD) can cause important damage.
Dissociation as Neurological Injury
A hypothesis connecting childhood surgical anesthesia, NMDA-system injury, and long-term dissociative symptoms
Inventing the future: A neuroscience research roadmap
The past decade of transformative advances in neurotechnology portends an exciting future for neuroscience. This NeuroView charts a strategic path to accelerate and integrate research discovery and speed the development of new cures for human brain disorders.
