Many people are asking for my opinion on the recent impressive success of AlphaFold at CASP14, perhaps incorrectly assuming that I am an expert on protein folding. I have actually never done any research in that field, but it's close enough to my research interests that I have closely followed the progress that has been made over the years. Rather than reply to everyone individually, here is a public version of my comments. They are based on the limited information on AlphaFold that is available today. I may come back to this post later and expand it.
Egon Willighagen (@egonw@social.edu.nl)
I commented on @PubPeer@mastodon.social on "Advances in nanomaterial-mediated CRISPR/Cas delivery: from lipid nanoparticles to vesicle-derived systems" https://doi.org/10.3389/fbioe.2025.1669104, that got published today. I don't do this often, and even hesitant to post here. But I have some questions: https://www.pubpeer.com/publications/E18F253C8EB7B947220AFDB4F608FC#1 I welcome if other people can also have a look. I did some journal editing yesterday, and that makes me sometimes more critical than I need to be.
Researchers | alphaXiv
Browse researcher profiles on alphaXiv: publications, citation metrics, research areas, and the papers behind them.
Atproto spaces alpha updates
Hey folks, we just launched the atproto spaces alpha. Check out the blog post for more details! Over the following weeks, we’ll be iterating on the specification and the implementation. In all likelihood, this will involve breaking changes to the PDS distribution, the Bluesky-hosted alpha PDS, and the alpha SDKs. To minimize disruption, we’ll plan to do releases on Thursdays (barring something critical that requires more immediate attention). When we do a release, We’ll make a post to this thr...
How small can ATproto get, really? - Unfolding Diagrams
Does an independent Bluesky stack really cost thousands?
How small can ATproto get, really? - Unfolding Diagrams
Does an independent Bluesky stack really cost thousands?
How small can ATproto get, really? - Unfolding Diagrams
Does an independent Bluesky stack really cost thousands?
How small can ATproto get, really? - Unfolding Diagrams
Does an independent Bluesky stack really cost thousands?
Post-alpha plans
Hey folks 👋 We’re about a month into the spaces alpha! From what I can tell, it’s going along pretty nicely. We pushed out one breaking change about two weeks back, but it’s been pretty stable apart from that. I wanted to share a list of some of the open questions we’re still noodling on. Many of these will likely involve breaking changes. Most of these are not truly “open”, we have opinions on them and need to just nail it down. However, if anything is important to you, please sha...
I'll just comment on my impressions of their conclusions in a thread here. Worth sharing how I see it unfolding internally. (I signed up for their email spam to read this so yes, I am a hero.)
Sue Smith
"The AI engineering impact data shows that output is up. It also shows that the work required to ensure that output is safe, correct, and maintainable has not decreased. It has increased substantially." Aye, if only any of us had been saying this from day one 🤡 faros.ai/blog/ai-acceleration-whiplash…
The most significant extension to the protocol since launch—atproto spaces—is now officially alpha software you can start testing with. Here's more about the goals and how to start testing. atproto.com/blog/atproto-spaces-alpha
The Atproto Spaces Alpha is Live
atproto.com_very_ alpha, but I've been messing with an atproto backfill/sync solution built on @cloudflare.social — currently has a couple caveats, and needs some work and docs, but the bones are there
GitHub - estrattonbailey/slipstream: Slipstream is a syncing and ingestion pipeline for atproto, built on Cloudflare.
github.comI'll just comment on my impressions of their conclusions in a thread here. Worth sharing how I see it unfolding internally. (I signed up for their email spam to read this so yes, I am a hero.)
Sue Smith
"The AI engineering impact data shows that output is up. It also shows that the work required to ensure that output is safe, correct, and maintainable has not decreased. It has increased substantially." Aye, if only any of us had been saying this from day one 🤡 faros.ai/blog/ai-acceleration-whiplash…
