It worked. Stem cells (mesenchymal) given to patients with a large heart attack reduced major adverse events in a randomized trial vs standard care bmj.com/content/391/bmj-2024-083382
Oct 29, 2025 at 11:21 PM
Stem cell therapy lowers risk of heart failure after a heart attack | New Scientist
People who receive stem cell therapy within a week of their first heart attack have nearly a 60 per cent lower risk of developing heart failure years later
Sleuths flag ‘complete mismatch’ in data of BMJ stem cell study | Manoj Lalu
This is disappointing, but I’m not surprised. I was one of the reviewers for the initial version. You can see by my review (it’s all open) that I flagged primary outcome switching, a complete lack of any data on the cells themselves, and sample size inconsistencies in the protocol versus the report (and within the report). The data seemed impressive. Too good to be true I guess? I never saw the paper again in peer review after that initial review. The next notification I received was that the paper was accepted. Given BMJ’s commitment to open peer review and post-publication scrutiny (which I admire), I have no doubt we will hear about a formal editorial investigation soon.
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Discover how a specialized AI model, GPT-4b micro, helped OpenAI and Retro Bio engineer more effective proteins for stem cell therapy and longevity research.
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Nikhil Krishnan on Twitter / X
yeah there used to be a company called Eureka that powered these types of observational, more lifestyle style studies (here's an example looking at coffee's effect on different biomarkers/conditions)https://t.co/urQRvTVTb7I think it can work if you have enough people in…— Nikhil Krishnan (@nikillinit) September 14, 2025
People who receive stem cell therapy within a week of their first heart attack have nearly a 60 per cent lower risk of developing heart failure years later
Stem cell therapy lowers risk of heart failure after a heart attack
www.newscientist.comAfter decades of mixed results, new evidence suggests stem cells really can help the heart heal. The largest trial yet finds stem cell therapy cuts the risk of heart failure by nearly 60% in the years following a heart attack. newscientist.com/article/2502081-stem-cell-the…
Stem cell therapy lowers risk of heart failure after a heart attack
www.newscientist.comDoes the new shingles vaccine (Shingrix) protect against cardiovascular disease (CVD)? Yes, according to a new 'natural experiment' study in @natmed.nature.com. But the truth is sadly far less convincing! Pull up a chair and let's examine another peer review failure in a Nature journal. 1/10 🧵
A challenge if anyone wants to take it up. Here is a recent review in the BMJ on the "Evidence for clinical interventions targeting the gut microbiome in cardiometabolic disease". There is not a single effect estimate reported in this review, or either supplemental file bmj.com/content/383/bmj-2023-075180
Evidence for clinical interventions targeting the gut microbiome in cardiometabolic disease
www.bmj.comI had strong priors against LLMs for medicine. There are a lot of doctors in my family and I grew up viewing doctors as careful, skilled professionals. I had plenty of bad medical experiences, but I thought it would be hard to do better. Then an LLM found a cure for my 2 decade chronic condition...
Seeing the "shingles vaccine protects from dementia" claim going around again. Unfortunately the main study it's based on is just not convincing. @epiellie.bsky.social has written a great post about why:
Shingles vaccine & dementia prevention: too good to be true?
medium.comI had strong priors against LLMs for medicine. There are a lot of doctors in my family and I grew up viewing doctors as careful, skilled professionals. I had plenty of bad medical experiences, but I thought it would be hard to do better. Then an LLM found a cure for my 2 decade chronic condition...
