How Explore Science reviews a manuscript: a mixture of frontier models, an in-house science stack and scientific agents, in a five-phase autonomous pipeline.
AI Scientists as Engines of Discovery: A Case for Development within Reformed Institutions
Agentic artificial intelligence (AI) systems are beginning to assist, accelerate, and partially automate scientific discovery, performing tasks that span literature synthesis, code generation, data analysis, hypothesis proposal, and model criticism. We argue that this transition is qualitative rather than incremental, and that suitably designed multi-agent systems may evolve from passive computational tools into ``AI scientists'' that can expand the hypothesis-generating and verification capacity of science. Such systems must be developed and deployed within a scientific ecosystem fit for purpose: institutions must be redesigned for verification, accountability, interpretability, and dual-use safety. We sketch how multi-agent architectures, illustrated by the prototype framework \textit{Denario}, accelerate the discovery cycle and traverse model spaces beyond human reach; examine what this implies for authorship, peer review, and the enduring role of human scientists; and close with recommendations for governing AI as an epistemic actor rather than a mere instrument.
AI has supercharged scientists—but may have shrunk science
Analysis of 41 million papers finds that although AI expands individual impact, it narrows collective scientific exploration
Guest post: If you’re going to critique science, be scientific about it
Loren K. Mell Editor’s note: This post responds to a Feb. 13 article in The Atlantic, “The Scientific Literature Can’t Save Us Now,” written by Retraction Watch cofounders Adam Marcus and Ivan Oran…
Continuous Science Foundation | Transform Science Together—Get Involved
Explore how the Continuous Science Foundation promotes open, continuous, and collaborative scientific research through innovative tools, standards, and community support.
No. 023: Co-Scientist, Terminal-Bench Science, AI in peer review - The Hallway Track
The Hallway Track No. 023 - How AI is affecting the practice of science
AI Research Agents Narrow Scientific Exploration
AI research agents now support large-scale AI-assisted scientific discovery. We examine whether AI-generated ideas broaden scientific exploration or primarily reinforce existing work. Using five agent frameworks and five large language models, we generate 219,655 ideas for different scientific fields. Across experiments, four consistent patterns emerge. First, AI-generated ideas are more concentrated than human-authored papers within the same research area. Second, they remain much closer to starting literature than later human follow-on work does. Third, AI-generated ideas align less with future human research. Last, AI-generated ideas are located in lower-impact regions of the historical scientific landscape. Overall, current AI research agents appear better suited to local elaboration than to broadening scientific exploration.
The Discovery Engine: A Framework for AI-Driven Synthesis and Navigation of Scientific Knowledge Landscapes
Scientific progress relies on the effective accumulation, synthesis, and critical evaluation of knowledge. Traditionally, the well-documented, peer reviewed publication served as the primary standard for filtering and disseminating credible findings within the scientific community. Recently, however, we are witnessing an unprecedented acceleration in research output, a veritable explosion of scientific publications across all disciplines [1]. Yet, this very abundance creates a paradox: the sheer volume threatens to overwhelm the mechanisms designed for its assimilation and synthesis. Researchers, even within highly specialized subfields, face an almost insurmountable challenge in keeping abreast of relevant developments, integrating disparate findings, and identifying the truly novel signals amidst the noise [2]. This information overload contributes to disciplinary fragmentation, hindering the cross-pollination of ideas essential for disruptive innovation [3]. Furthermore, persistent concerns regarding "reproducibility crisis" [2], predatory journals, inflation of research areas[4], growing retractions and the potential influences of bibliometrics on research direction [5] highlight systemic challenges in validating and prioritizing scientific contributions to fundamental knowledge.
No. 027: AGMAI advisory group, Millennium Problems for biology, autonomous research pipelines - The Hallway Track
The Hallway Track No. 027 - How AI is affecting the practice of science
TERMINAL-BENCH-SCIENCE
A benchmark for evaluating AI agents on research workflows across scientific domains
The Current Crisis: What's Happening to Science in America
A budding discipline around how science gets read and judged - Aris
Scholarly publishing spent thirty years arguing about access. It has barely begun arguing about what readers do with the paper once they have it. At Aris we call that second argument scholarly interface design. Mike Morrison's community calls it ScienceUX. Either way it is becoming a field, and here is why it is worth your attention.
Agentic Laboratories of the Future: Towards World Models for Scientific Discovery
Scientific discovery is fundamentally a problem-solving process involving distributed intelligence. Human intuition, computational reasoning, and experimental execution are distributed across people, instruments, and software systems, limiting the speed and scale of discovery. Although automation, high-throughput experimentation, foundation models, and cloud infrastructure have accelerated individual stages of the scientific workflow, they have not unified the discovery process. We hypothesize that the next generation of laboratories will be agentic: environments in which scientists, AI systems, and robotic platforms operate as collaborative discovery partners, with humans contributing the parts of discovery that remain hardest to make explicit: asking the right questions and holding provisional mechanistic models of how a system works. The key missing layer is an agentic harnessing layer that continuously integrates hypothesis, literature-derived evidence, experimental data, uncertainty, and experimental state into a shared “laboratory world model”—a dynamic representation of the scientific system and its evolving context. By maintaining and updating this lab world model, the agentic harnessing layer enables coordinated decision-making, adaptive planning, and increasingly autonomous scientific workflows across humans and machines. A central challenge is that much of the scientific research process remains inaccessible to machines, including tacit knowledge, human observations, adaptive decision-making, and evolving experimental context. Advances in multimodal AI and immersive interfaces may help bridge this gap, allowing humans, agents, and robotic systems to collaborate seamlessly in scientific discovery rather than simply automating isolated tasks. Agentic laboratories could provide a new architecture for science, integrating human, artificial, and physical intelligence into a unified discovery system.
From Grants to Portfolios: Index Logic for Science
How science can learn from capital markets to coordinate diversity, measure progress, and turn discovery into a public portfolio.
AI, peer review and the human activity of science
When researchers cede their scientific judgement to machines, we lose something important.
