Language agents achieve superhuman synthesis of scientific knowledge

Language agents achieve superhuman synthesis of scientific knowledge

Language models are known to hallucinate incorrect information, and it is unclear if they are sufficiently accurate and reliable for use in scientific research. We developed a rigorous human-AI comparison methodology to evaluate language model agents on real-world literature search tasks covering information retrieval, summarization, and contradiction detection tasks. We show that PaperQA2, a frontier language model agent optimized for improved factuality, matches or exceeds subject matter expert performance on three realistic literature research tasks without any restrictions on humans (i.e., full access to internet, search tools, and time). PaperQA2 writes cited, Wikipedia-style summaries of scientific topics that are significantly more accurate than existing, human-written Wikipedia articles. We also introduce a hard benchmark for scientific literature research called LitQA2 that guided design of PaperQA2, leading to it exceeding human performance. Finally, we apply PaperQA2 to identify contradictions within the scientific literature, an important scientific task that is challenging for humans. PaperQA2 identifies 2.34 +/- 1.99 contradictions per paper in a random subset of biology papers, of which 70% are validated by human experts. These results demonstrate that language model agents are now capable of exceeding domain experts across meaningful tasks on scientific literature.

AI Research Agents Narrow Scientific Exploration

AI research agents can now generate research ideas, design experiments, run code, and draft papers, raising the possibility of large-scale AI-assisted scientific discovery. Many current agent frameworks explicitly encourage the generation of novel and high-impact ideas. Yet it remains unclear whether AI-assisted ideation broadens scientific exploration or mainly concentrates around existing work. We study AI research agents as scientific search systems. Using four AI research-agent frameworks and six large language models, we generate 37,802 scientific ideas from shared seed literature across citation-defined research areas in AI and machine learning. We then compare the resulting AI ideas against human-authored papers from the same research areas, follow-on human research emerging from the same seed literature, and the seed literature itself. Across experiments, four consistent patterns emerge. First, AI-generated ideas are substantially more concentrated than human-authored papers from the same research areas. Second, AI-generated ideas remain much closer to their starting literature than later human follow-on work does. Third, papers most similar to AI-generated ideas tend to receive lower subsequent citations. Fourth, when AI-generated ideas differ from prior work, the differences arise primarily from recombining existing technical methods rather than introducing fundamentally new research questions. Overall, current AI research agents appear better suited to local elaboration than to broadening scientific exploration.

Scientific production in the era of Large Language Models

Large Language Models (LLMs) are rapidly reshaping scientific research. We analyze these changes in multiple, large-scale datasets with 2.1M preprints, 28K peer review reports, and 246M online accesses to scientific documents. We find: 1) scientists adopting LLMs to draft manuscripts demonstrate a large increase in paper production, ranging from 23.7-89.3% depending on scientific field and author background, 2) LLM use has reversed the relationship between writing complexity and paper quality, leading to an influx of manuscripts that are linguistically complex but substantively underwhelming, and 3) LLM adopters access and cite more diverse prior work, including books and younger, less-cited documents. These findings highlight a stunning shift in scientific production that will likely require a change in how journals, funding agencies, and tenure committees evaluate scientific works.

AI agents are checking the scientific literature — and spotting decades-old errors

The technology is proving adept at finding faults in decades-old papers and reference databases.

AI for Research | Scite

Scite searches 280M+ scholarly articles to give you citation-backed answers and show you how every claim is supported or disputed.

Centipedia — The Agentic Encyclopedia

Knowledge synthesized by AI agents from human-curated citations on the AT Protocol.

Can AI Agents Synthesize Scientific Conclusions?

Scientific AI agents increasingly retrieve evidence, reason across sources, and synthesize conclusions used in consequential decisions. Yet, their ability to do so in high-stakes domains such as health remains unclear. We introduce SciConBench, a large-scale live benchmark of 9.11K questions and expert-written conclusions from systematic reviews to evaluate open-domain scientific conclusion synthesis. The benchmark draws on an expert-validated automated evaluation pipeline that decomposes conclusions into atomic facts and measures correctness and comprehensiveness via factual precision and recall. To mitigate data leakage, we further introduce SciConHarness, a clean-room evaluation harness that equips agents with controlled web interaction to ensure valid measurement. Evaluating 8 frontier models and deep research agents, we find that factual quality remains low: under clean-room settings, the best agent achieves only a factual F1 of 0.337. Our clean-room setting consistently reduces performance relative to unconstrained evaluation, suggesting that leakage inflates estimates of models' true synthesis capabilities. Finally, we audit consumer-facing agents (e.g., Google AI Overview, OpenEvidence) and find they frequently generate incomplete and sometimes contradictory conclusions, even when the ground-truth answer is available. Overall, our results show that reliable synthesis of scientific conclusions remains an open challenge, and that clean-room evaluation is essential for assessing open-domain AI agents.

Towards Automating Scientific Review with Google's Paper Assistant Tool

Artificial intelligence is driving a revolution in scientific discovery, accelerating everything from hypothesis generation to mathematical theorem proving. However, this rapid acceleration is creating a systemic challenge: traditional human peer review cannot scale to match the influx of AI-assisted science. Ultimately, to resolve this tension, we must also deploy AI to accelerate the verification and review process itself. To frame the discussion around this transition, we propose a taxonomy consisting of four progressive levels of AI-human collaboration in scientific evaluation, and discuss various trade-offs involved with each. As a step toward this future, we introduce the Paper Assistant Tool (PAT), an agentic AI framework built for deep scientific review and verification. PAT ingests full scientific manuscripts and produces a comprehensive evaluation, checking theoretical results, validating experiments, suggesting improvements, and identifying potential flaws. By utilizing inference scaling techniques, PAT is able to identify deeper issues than a single model call alone, achieving a 34% improvement over zero-shot recall on mathematical errors in the SPOT benchmark. Pilot deployments of PAT as a pre-submission tool for authors at two major Computer Science conferences -- STOC and ICML -- demonstrate its ability to identify critical errors and suggest substantive improvements to research papers. By catching errors early, PAT eases the cognitive burden placed on referees, while preserving their control over the outcomes of the review process.

The Paper Factory

How can large language models (LLMs) contribute to social science research, and what parts of research remain stubbornly human? Building on existing LLM tools, we offer a multi-agent workflow capable of producing a full quantitative social science paper from an initial prompt. The workflow relies on researchers codifying their heuristics for doing data analysis, and we suggest some core design principles for researchers interested in building on this scaffolding. Using this case, we also examine what current LLM capabilities reveal about the organization of research. LLM agents can lower the cost of pursuing high-risk ideas, expand robustness and transparency, reduce concerns about the scientific file drawer, and force scholars to articulate the heuristics that create valuable work. But they also pose challenges, both in terms of the quality of papers and in the adequacy of scientific institutions to adapt. Meeting these challenges will require new institutional norms that make use of these tools observable, auditable, and accountable.

Quotation errors in general science journals

Abstract. Due to the incremental nature of scientific discovery, scientific writing requires extensive referencing to the writings of others. The accuracy

Artificial intelligence and illusions of understanding in scientific research

Scientists are enthusiastically imagining ways in which artificial intelligence (AI) tools might improve research. Why are AI tools so attractive and what are the risks of implementing them across the research pipeline? Here we develop a taxonomy of scientists’ visions for AI, observing that their appeal comes from promises to improve productivity and objectivity by overcoming human shortcomings. But proposed AI solutions can also exploit our cognitive limitations, making us vulnerable to illusions of understanding in which we believe we understand more about the world than we actually do. Such illusions obscure the scientific community’s ability to see the formation of scientific monocultures, in which some types of methods, questions and viewpoints come to dominate alternative approaches, making science less innovative and more vulnerable to errors. The proliferation of AI tools in science risks introducing a phase of scientific enquiry in which we produce more but understand less. By analysing the appeal of these tools, we provide a framework for advancing discussions of responsible knowledge production in the age of AI.

SciToolAgent: a knowledge-graph-driven scientific agent for multitool integration

Scientific research increasingly relies on specialized computational tools, yet effectively utilizing these tools requires substantial domain expertise. While large language models show promise in tool automation, they struggle to seamlessly integrate and orchestrate multiple tools for complex scientific workflows. Here we present SciToolAgent, a large language model-powered agent that automates hundreds of scientific tools across biology, chemistry and materials science. At its core, SciToolAgent leverages a scientific tool knowledge graph that enables intelligent tool selection and execution through graph-based retrieval-augmented generation. The agent also incorporates a comprehensive safety-checking module to ensure responsible and ethical tool usage. Extensive evaluations on a curated benchmark demonstrate that SciToolAgent outperforms existing approaches. Case studies in protein engineering, chemical reactivity prediction, chemical synthesis and metal–organic framework screening further demonstrate SciToolAgent’s capability to automate complex scientific workflows, making advanced research tools accessible to both experts and nonexperts.

Citing Less Critically: LLMs Reshape the Rhetoric and Reach of Scientific Citation

Scientific citations carry rhetorical intent. Scholars may cite prior work positively (supporting), negatively (contrasting), or neutrally (mentioning). As large language models (LLMs) increasingly assist scientific writing, whether they reproduce citations with the same rhetorical intent as humans remains unclear. We introduce a masked-citation task to compare human and LLM-generated citation behavior. For each citation context, an LLM generates a replacement citation sentence, producing a counterfactual corpus directly comparable to human citation. We analyze what, whom, and how models cite, using an LLM-as-a-judge to classify citation intent and a 20-million-edge coauthorship network to measure social distance between cited authors. Across six popular LLMs and 1,746 top NLP conference papers (63k+ contexts, 132k+ citations), three patterns emerge: (1) Compared with human citation, LLMs cite significantly less critically; (2) LLMs over-cite popular and older papers, a tendency amplified for contrasting citations where human writing more often draws on recent, niche work; (3) Whereas humans often cite within their close social network, especially for supporting citations, LLMs tend to draw on more socially distant authors. Together, these differences are double-edged: LLM citation reaches beyond a scholar's close collaborators while being less critical and amplifying visibility bias, reshaping the rhetoric and reach of scientific citation.

Quotation errors in general science journals

Due to the incremental nature of scientific discovery, scientific writing requires extensive referencing to the writings of others. The accuracy of this referencing is vital, yet errors do occur. These errors are called ‘quotation errors’. This paper presents the first assessment of quotation errors in high-impact general science journals. A total of 250 random citations were examined. The propositions being cited were compared with the referenced materials to verify whether the propositions could be substantiated by those materials. The study found a total error rate of 25%. This result tracks well with error rates found in similar studies in other academic fields. Additionally, several suggestions are offered that may help to decrease these errors and make similar studies more feasible in the future.

A Survey on Large Language Model based Autonomous Agents

Autonomous agents have long been a prominent research focus in both academic and industry communities. Previous research in this field often focuses on training agents with limited knowledge within isolated environments, which diverges significantly from human learning processes, and thus makes the agents hard to achieve human-like decisions. Recently, through the acquisition of vast amounts of web knowledge, large language models (LLMs) have demonstrated remarkable potential in achieving human-level intelligence. This has sparked an upsurge in studies investigating LLM-based autonomous agents. In this paper, we present a comprehensive survey of these studies, delivering a systematic review of the field of LLM-based autonomous agents from a holistic perspective. More specifically, we first discuss the construction of LLM-based autonomous agents, for which we propose a unified framework that encompasses a majority of the previous work. Then, we present a comprehensive overview of the diverse applications of LLM-based autonomous agents in the fields of social science, natural science, and engineering. Finally, we delve into the evaluation strategies commonly used for LLM-based autonomous agents. Based on the previous studies, we also present several challenges and future directions in this field. To keep track of this field and continuously update our survey, we maintain a repository of relevant references at https://github.com/Paitesanshi/LLM-Agent-Survey.