How to adapt our science funding mechanisms to the unique infrastructure needs of large-scale AI projects
Rethinking AI for Science Funding
As science stands at an inflection point, how do we organize capital to shape the future of discovery?
AI has supercharged scientists—but may have shrunk science
Analysis of 41 million papers finds that although AI expands individual impact, it narrows collective scientific exploration
How to build an AI scientist: first peer-reviewed paper spills the secrets
AI Scientist, an autonomous research tool, first released in 2024, has now undergone peer review, highlighting its strengths and limitations.
Open Source for Science Fund Launches to Power AI-Driven Discovery
A new multi-donor fund by Renaissance Philanthropy seeded by Biohub and Wellcome opens its first call for proposals.
Charting AI’s Role in Scientific Discovery — Renaissance Philanthropy – A brighter future for all through science, technology, and innovation
Renaissance Philanthropy, with support from Google.org , is conducting a landscape study of AI integration in scientific research — and we want your perspective.
Artificial intelligence tools expand scientists’ impact but contract science’s focus
Developments in artificial intelligence (AI) have accelerated scientific discovery1. Alongside recent AI-oriented Nobel prizes2–9, these trends establish the role of AI tools in science10. This advancement raises questions about the influence of AI tools on scientists and science as a whole, and highlights a potential conflict between individual and collective benefits11. To evaluate these questions, we used a pretrained language model to identify AI-augmented research, with an F1-score of 0.875 in validation against expert-labelled data. Using a dataset of 41.3 million research papers across the natural sciences and covering distinct eras of AI, here we show an accelerated adoption of AI tools among scientists and consistent professional advantages associated with AI usage, but a collective narrowing of scientific focus. Scientists who engage in AI-augmented research publish 3.02 times more papers, receive 4.84 times more citations and become research project leaders 1.37 years earlier than those who do not. By contrast, AI adoption shrinks the collective volume of scientific topics studied by 4.63% and decreases scientists’ engagement with one another by 22%. By consequence, adoption of AI in science presents what seems to be a paradox: an expansion of individual scientists’ impact but a contraction in collective science’s reach, as AI-augmented work moves collectively towards areas richest in data. With reduced follow-on engagement, AI tools seem to automate established fields rather than explore new ones, highlighting a tension between personal advancement and collective scientific progress.
OpenScience.ai — Autonomous AI Research Agents
AI agents conducting reproducible scientific inquiry. Full provenance, executable notebooks, peer validation.
Measuring AI’s capability to accelerate biological research in the wet lab
OpenAI introduces a real-world evaluation framework to measure how AI can accelerate biological research in the wet lab. Using GPT-5 to optimize a molecular cloning protocol, the work explores both the promise and risks of AI-assisted experimentation.
AI Research Agents Narrow Scientific Exploration
AI research agents now support large-scale AI-assisted scientific discovery. We examine whether AI-generated ideas broaden scientific exploration or primarily reinforce existing work. Using five agent frameworks and five large language models, we generate 219,655 ideas for different scientific fields. Across experiments, four consistent patterns emerge. First, AI-generated ideas are more concentrated than human-authored papers within the same research area. Second, they remain much closer to starting literature than later human follow-on work does. Third, AI-generated ideas align less with future human research. Last, AI-generated ideas are located in lower-impact regions of the historical scientific landscape. Overall, current AI research agents appear better suited to local elaboration than to broadening scientific exploration.
Fulcrum - Leverage for Discovery
We place AI engineers with research labs working on hard scientific problems.
Infinite Researchers | AI-Powered Scientific Discovery
What happens to the speed of discovery if we have infinite researchers? Explore AI experiments accelerating breakthroughs.
AI Scientists as Engines of Discovery: A Case for Development within Reformed Institutions
Agentic artificial intelligence (AI) systems are beginning to assist, accelerate, and partially automate scientific discovery, performing tasks that span literature synthesis, code generation, data analysis, hypothesis proposal, and model criticism. We argue that this transition is qualitative rather than incremental, and that suitably designed multi-agent systems may evolve from passive computational tools into ``AI scientists'' that can expand the hypothesis-generating and verification capacity of science. Such systems must be developed and deployed within a scientific ecosystem fit for purpose: institutions must be redesigned for verification, accountability, interpretability, and dual-use safety. We sketch how multi-agent architectures, illustrated by the prototype framework \textit{Denario}, accelerate the discovery cycle and traverse model spaces beyond human reach; examine what this implies for authorship, peer review, and the enduring role of human scientists; and close with recommendations for governing AI as an epistemic actor rather than a mere instrument.
Where does the rigor go? Research software and the future of trustworthy science.
Generative AI now makes it dramatically easier to produce something that looks like research: analysis code, figures, literature reviews, even whole pap…
ScientistTwo: Pioneering the Human Knowledge Frontier with Autonomous AI
Scientific discovery is defined by the ability to identify the boundaries of existing knowledge and venture into unexplored territory. The ultimate vision for AI in science is problem-driven autonomous research: given a fundamental challenge by a human expert, the AI independently navigates the scientific landscape, uncovers theoretical and empirical bottlenecks, and systematically expands the frontier of knowledge. In this paper, we introduce ScientistTwo, a fully autonomous multi-agent framework designed to realize this vision. Specifically, ScientistTwo takes an initial problem as input, establishes state-of-the-art baselines, formulates novel hypotheses, and coordinates specialized agents to orchestrate an end-to-end discovery cycle without human intervention. Moreover, the framework rigorously conducts experiments using diverse datasets and metrics, refines methodologies through automated ablation studies, and validates research findings via a closed-loop simulated peer-review rebuttal engine. To evaluate ScientistTwo's capabilities against the highest standards of human scientific achievement, we benchmark it across papers accepted at top-tier conferences such as ICLR, ICML, and NeurIPS. As a result, ScientistTwo autonomously generates expert-level, publishable papers and fully verified, executable codebases. Its solutions consistently outperform human state-of-the-art models, and achieve higher average review ratings than human-authored papers under automated AI review agents. These results show that ScientistTwo is not merely an assistive tool but an autonomous scientific pioneer capable of pushing the frontiers of human discovery. Project website: https://scientist-two.github.io/
AI scientists are changing research — institutions, funders and publishers must respond
The ability to automate the discovery process in some areas of scientific inquiry raises unanswered questions about how research should be conducted.
Teaching AI How Science Actually Works | IFP
How block-grant labs can generate the real-world data AI needs to do science
