This is the most important column I’ve ever written. The message is quite complex--dozens of new health parameters to test for and to optimize, all of them interacting in ways that will require new training for MDs.
We Are Entering the Age of Alzheimer's
We will all be touched by the disease. How are we going to get through this?
How Exercise Might "Clean" the Alzheimer's Brain
Hints at potential treatments for age-related dementia and memory loss
Learning What Substance Is Suspected of Causing Alzheimer’s May Throw You Into an Existential Crisis
A surprisingly common substance was found to have a causal relationship with the kind of brain damage associated with Alzheimer's disease.
Unconventional But Effective Therapy for Alzheimer's Treatment: Dr. Mary T. Newport at TEDxUSF
Inventing the future: A neuroscience research roadmap
The past decade of transformative advances in neurotechnology portends an exciting future for neuroscience. This NeuroView charts a strategic path to accelerate and integrate research discovery and speed the development of new cures for human brain disorders.
Leading Innovation in Psychiatric Treatment | Alto Neuroscience
We leverage brain biology to develop personalized medicines, helping patients get better faster.
Can Alzheimer’s really be reversed, as a new documentary claims?
A CNN documentary follows two people with Alzheimer’s who took part in a study to determine if lifestyle changes can reverse symptoms.
Breakthrough ultrasound treatment to reverse dementia moves to human trials
An extraordinarily promising new technique using ultrasound to clear the toxic protein clumps thought to cause dementia and Alzheimer's disease is moving to the first phase of human trials next year. The innovative treatment has proven successful across several animal tests and presents an exciting, drug-free way to potentially battle dementia.
The Terrorist in the Brain
What can Robin Williams and Bruce Willis teach us about dementia? This article explores the complex biological realities of brain diseases, controversies in Alzheimer's research, the risks of new drugs, and the multi-billion-dollar industry exploiting our fear of cognitive decline.
I’m going to cure my girlfriend’s brain tumor.
Launch of an experiment to use AI-Scientists to accelerate research of a "solved" disease.
Study Reveals a Surprising Cause of Cognitive Decline—and the Key to Reversing It
Researchers pinpoint a lone protein that speeds up the dysfunction of an aging brain. Eliminating it, they claim, can reverse the damage. But there are big hurdles before a treatment is approved.
Precision Medicine in Neuroscience: Tools, Translation, and Implementation: A Workshop
Precision medicine approaches are rapidly transforming neuroscience, driven by advances in genetics, neuroimaging, biomarkers, and data science. These tools enable more refined disease classification, improved diagnosis, and treatments tailored to individual patients across neurological and psychiatric disorders. However, challenges remain in translating these advances into routine research and clinical practice. On March 4–5, the National Academies’ Forum on Neuroscience and Nervous System Disorders, in collaboration with the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health, will host a workshop exploring opportunities, challenges, and strategies for integrating precision medicine into neuroscience research and care.
Small Trial Reverses a Year of Alzheimer's Cognitive Decline in Just Two Months
The next step is a clinical trial with 150 people.
Ramez Naam on Twitter / X
There was a site years ago called CureTogether where patients could share information in a structured way on their disease, regimen, and progress, working towards a sort of bottoms-up clinical trial. 23andMe acquired them and it seems to be mostly dead.— Ramez Naam (@ramez) September 14, 2025
Computational Psychiatry Needs Systems Neuroscience
This piece was originally published in The Transmitter. I am adapting it here with some additional context for readers of this newsletter.
Seeing the "shingles vaccine protects from dementia" claim going around again. Unfortunately the main study it's based on is just not convincing. @epiellie.bsky.social has written a great post about why:
Shingles vaccine & dementia prevention: too good to be true?
medium.com