The use of herbal medicines is common in Africa, and patients often use a combination of herbs and drugs. Concurrent herbal and pharmaceuticals treatments can cause adverse effects through herb-drug interactions (HDI). This study evaluated the potential risk of HDI for five medicinal plants, Vernonia amygdalina, Ocimum gratissimum, Moringa oleifera, Azadirachta indica, and Picralima nitida, using in vitro assays. Patients with diabetes and some other disease conditions commonly use these medicinal plants in Nigeria, and little is known regarding their potential for drug interaction, despite their enormous use.
Beneficial Plant Research Association
Medicinal, useful, and nutritious plants hold the potential to restore both human health and ecological balance.
Biophoton emission promotes the modern scientific utilization of medicinal plants: from theoretical integration to research applications
Medicinal plants constitute the primary pharmacological source of Chinese medicine and their scientific interpretation is crucial for quality standardization and clinical guidance. Paradoxically, the contemporary evaluation model primarily adopts ...
Soy consumption and serum uric acid levels: A systematic review and meta-analysis
BackgroundSoy consumption has health benefits, but the relationship between soy and uric acid remains uncertain. This meta-analysis and systematic review evaluated effects of soy intake on plasma uric acid.MethodsPubMed, Embase, CNKI, and the Cochrane Library were searched for studies evaluating the effects of soy, soy products, soy protein, and soy isoflavones on uric acid levels. The primary outcome was serum or plasma uric acid concentration. Study quality was evaluated by the Cochrane Collaboration and SYRCLE risk-of-bias tools.ResultsSeventeen studies were included. Qualitative analysis of three human clinical studies of acute effects revealed that soy consumption increased serum uric acid concentration; however, soy-derived products, including tofu, bean curd cake, and dried bean curd sticks, had no significant effect on serum uric acid. Meta-analysis of five long-term human studies (10 data sets) revealed that soy protein and soy isoflavones had no significant effects on uric acid levels (weighted mean difference [WMD] = −2.11; 95% confidence interval [CI]: −8.78, 4.55; p = 0.53). However, most epidemiological data revealed that soy intake is inversely associated with uric acid levels. Meta-analysis of nine animal trials (29 data sets) revealed that soy protein and soy isoflavones significantly reduced serum uric acid concentrations (vs. controls; MD = −38.02; 95% CI: −50.60, −25.44; p < 0.001). ConclusionSoy and its products have different effects on serum uric acid. Soy products like tofu, bean curd cake, and dried bean curd sticks could be high-quality protein sources for individuals with hyperuricemia or gout. It can be beneficial to nutritionists and health-care decision makers reconsider their conceptions about the relationship between soy and uric acid levels according to latest and further scientific study results.
Marina Silva é o principal alvo de ofensas contra candidatas no X
Levantamento do MonitorA revela que 63% dos ataques e insultos foram feitos contra candidatas ao Senado; disputa por cargo considerado estratégico nas eleições deste ano mobilizou comentários ofensivos contra mulheres
A Dose of a Hallucinogen From a ‘Magic Mushroom,’ and Then Lasting Peace (Published 2016)
Two studies used psilocybin to see if the drug could reduce depression and anxiety in cancer patients. The results were striking.
Bilingual Glossary - Food and Drug Administration, Department of Health
I've Been Writing About AI for Two Years. I Was Looking at the Wrong Part of the World.
There is an app in Lagos that can tell you whether your malaria medication is real or counterfeit.
Opinion | Treat Medicines Like Netflix Treats Shows (Published 2019)
Australia seems to have found a way to entice Big Pharma into making essential new medicines affordable. Why can’t the United States?
Pharmacometrics and systems pharmacology for metabolic bone diseases
Mathematical modelling and simulation (M&S) of drug concentrations, pharmacologic effects and the (patho)physiologic systems within which they interact can be powerful tools for the preclinical, translational and clinical development of drugs. Indeed, the Prescription Drug User Fee Act (PDUFA VI), incorporated as part of the FDA Reauthorization Act of 2017 (FDARA), highlights the goal of advancing model‐informed drug development (MIDD). MIDD can benefit development across many drug classes, including for metabolic bone diseases such as osteoporosis, cancer‐related and numerous rare metabolic bone diseases; conditions characterized by significant morbidity and mortality. A drought looms in terms of the availability of new drugs to better treat these devastating diseases. This review provides an overview of several M&S approaches ranging from simple pharmacokinetic to integrated pharmacometric and systems pharmacology modelling. Examples are included to illustrate the use of these approaches during the development of several drugs for metabolic bone diseases such as bisphosphonates, denosumab, teriparatide and sclerostin inhibitors (romosozumab and blosozumab).
100 aliments bons pour la santé à prix coûtant
« Manger 5 fruits et légumes par jour », « privilégier les céréales complètes », « cuisiner maison » ou « consommer des produits biologiques » : tout le monde connait ces recommandations de santé publique par cœur. Mais dans les supermarchés, les respecter est bien plus compliqué. En réalité, trop peu de personnes en France peuvent se permettre de suivre ces conseils de santé publique, pourtant élaborés pour s’alimenter sainement au quotidien et réduire les risques de maladies évitables liées à l’alimentation (diabète, maladies cardio-vasculaires, cancers…).
Specific inulin‐type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function, and microbiota homeostasis
Scope Dietary fibers capable of modifying gut barrier and microbiota homeostasis affect the progression of type 1 diabetes (T1D). Here, we aim to compare modulatory effects of inulin‐type fructans (ITFs), natural soluble dietary fibers with different degrees of fermentability from chicory root, on T1D development in nonobese diabetic mice. Methods and results Female nonobese diabetic mice were weaned to long‐ and short‐chain ITFs [ITF(l) and ITF(s), 5%] supplemented diet up to 24 weeks. T1D incidence, pancreatic‐gut immune responses, gut barrier function, and microbiota composition were analyzed. ITF(l) but not ITF(s) supplementation dampened the incidence of T1D. ITF(l) promoted modulatory T‐cell responses, as evidenced by increased CD25 + Foxp3 + CD4 + regulatory T cells, decreased IL17A + CD4 + Th17 cells, and modulated cytokine production profile in the pancreas, spleen, and colon. Furthermore, ITF(l) suppressed NOD like receptor protein 3 caspase‐1‐p20‐IL‐1β inflammasome in the colon. Expression of barrier reinforcing tight junction proteins occludin and claudin‐2, antimicrobial peptides β‐defensin‐1, and cathelicidin‐related antimicrobial peptide as well as short‐chain fatty acid production were enhanced by ITF(l). Next‐generation sequencing analysis revealed that ITF(l) enhanced Firmicutes/Bacteroidetes ratio to an antidiabetogenic balance and enriched modulatory Ruminococcaceae and Lactobacilli . Conclusion Our data demonstrate that ITF(l) but not ITF(s) delays the development of T1D via modulation of gut‐pancreatic immunity, barrier function, and microbiota homeostasis.
Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males
Consumption of caffeine-rich beverages, which have diuretic properties, may decrease serum uric acid concentrations. We examined cross-sectionally the relationship of coffee and green tea consumption to serum uric acid concentrations in 2240 male self-defence officials who received a pre-retirement health examination at four hospitals of the Self-Defence Forces between 1993 and 1994. The mean levels of coffee and green tea consumption were 2·3 and 3·1 cups/d respectively. There was a clear inverse relationship between coffee consumption and serum uric acid concentration. When adjusted for hospital only, those consuming less than one cup of coffee daily had a mean serum uric acid concentration of 60 mg/l, while that of those drinking five or more cups of coffee daily was 56 mg/l (P < 0·0001). No such relationship was observed for green tea, another major dietary source of caffeine in Japan. The relationship between coffee consumption and serum uric acid concentration was independent of age, rank in the Self-Defence Forces, BMI, systolic blood pressure, serum creatinine, serum total cholesterol and serum HDL-cholesterol concentrations, smoking status, alcohol use, beer consumption and intake of dairy products. These findings suggest that coffee drinking may be associated with lower concentrations of serum uric acid, and further studies are needed to confirm the association.
Taian® Tea | Premium Chinese Tea & Herbal Wellness
Traditional and herbal teas from Taian Tea - discover premium tea varieties, health benefits, and authentic tea culture.
Opinion | How to Win a War on Drugs (Published 2017)
Portugal treats addiction as a disease, not a crime.
Japanese Pharmacopoeia
This database includes English name, structural formula, molecular formula and molecular mass, chemical name and CAS registry number of "the Japanese Pharmacopoeia".
Long-term study reveals harm in regular cannabis use
Regular cannabis use has harmful effects regardless of the age a person starts using, a University of Queensland-led study has found.
