







In this essay, I discuss Dennett’s From Bacteria to Bach and Back: The Evolution of Minds (hereafter From Bacteria) and Godfrey Smith’s Other Minds: The Octopus and The Evolution of Intelligent Life (hereafter Other Minds) from a methodological perspective. I show that these both instantiate what I call ‘synthetic philosophy.’ They are both Darwinian philosophers of science who draw on each other’s work (with considerable mutual admiration). In what follows I first elaborate on synthetic philosophy in light of From Bacteria and Other Minds; I also explain my reasons for introducing the term; and I close by looking at the function of Darwinism in contemporary synthetic philosophy.
From Bacteria to Bach and Back
'A supremely enjoyable, intoxicating work.' —<em>Nature</em>, From Bacteria to Bach and Back, The Evolution of Minds, Daniel C Dennett, 9780393355505

The sentient cell: the cellular foundations of consciousness
"All species, extant and extinct, from the simplest unicellular prokaryotes to humans, have an existential consciousness. Without sentience, the first cells that emerged some 4 billion years ago would have been evolutionary dead-ends, unable to survive in the chaotic, dangerous environment in which life first appeared and evolved. In this book, Arthur Reber's theory, the Cellular Basis of Consciousness (CBC), is outlined and distinguished from those models that argue that minds could be instantiated on artificial entities and those that maintain consciousness requires a nervous system. The CBC framework takes a novel approach to classic topics such as the origin-of-life, philosophy of mind, the role of genes, the impact of cognition, and how biological information is processed by all species. It also calls for a rethinking of a variety of issues including the moral implications of the sentient capacities of all species, how welfare concerns need to be expanded beyond where they currently are, and critically, how all life is intertwined in a coordinated cognitive ecology. The Sentient Cell explores this revolutionary model, which updates the standard neo-Darwinian framework within which current approaches operate and examines the underlying biomolecular features that are the likely candidates for the "invention" of consciousness and outline their role in cellular life." --

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds
Synthetic biology and bioengineering provide the opportunity to create novel embodied cognitive systems (otherwise known as minds) in a very wide variety of chimeric architectures combining evolved and designed material and software. These advances are disrupting familiar concepts in the philosophy of mind, and require new ways of thinking about and comparing truly diverse intelligences, whose composition and origin are not like any of the available natural model species. In this Perspective, I introduce TAME-Technological Approach to Mind Everywhere-a framework for understanding and manipulating cognition in unconventional substrates. TAME formalizes a non-binary (continuous), empirically-based approach to strongly embodied agency. TAME provides a natural way to think about animal sentience as an instance of collective intelligence of cell groups, arising from dynamics that manifest in similar ways in numerous other substrates. When applied to regenerating/developmental systems, TAME suggests a perspective on morphogenesis as an example of basal cognition. The deep symmetry between problem-solving in anatomical, physiological, transcriptional, and 3D (traditional behavioral) spaces drives specific hypotheses by which cognitive capacities can increase during evolution. An important medium exploited by evolution for joining active subunits into greater agents is developmental bioelectricity, implemented by pre-neural use of ion channels and gap junctions to scale up cell-level feedback loops into anatomical homeostasis. This architecture of multi-scale competency of biological systems has important implications for plasticity of bodies and minds, greatly potentiating evolvability. Considering classical and recent data from the perspectives of computational science, evolutionary biology, and basal cognition, reveals a rich research program with many implications for cognitive science, evolutionary biology, regenerative medicine, and artificial intelligence.

The cognitive cell: bacterial behavior reconsidered
Research on how bacteria adapt to changing environments underlies the contemporary biological understanding of signal transduction, and signal transduction provides the foundation of the information-processing approach that is the hallmark of the ‘cognitive revolution,’ which began in the mid-20th century. Yet cognitive scientists largely remain oblivious to research into microbial behavior that might provide insights into problems in their own domains, while microbiologists seem equally unaware of the potential importance of their work to understanding cognitive capacities in multicellular organisms, including vertebrates. Evidence in bacteria for capacities encompassed by the concept of cognition is reviewed. Parallels exist not only at the heuristic level of functional analogue, but also at the level of molecular mechanism, evolution and ecology, which is where fruitful cross-fertilization among disciplines might be found.

AI creates first synthetic viruses
Genomic language model has huge potential to redesign organisms such as bacteria

Conscious artificial intelligence and biological naturalism
As artificial intelligence (AI) continues to advance, it is natural to ask whether AI systems can be not only intelligent, but also conscious. I consider why people might think AI could develop consciousness, identifying some biases that lead us astray. I ask what it would take for conscious AI to be a realistic prospect, challenging the assumption that computation provides a sufficient basis for consciousness. I'll instead make the case that consciousness depends on our nature as living organisms – a form of biological naturalism. I lay out a range of scenarios for conscious AI, concluding that real artificial consciousness is unlikely along current trajectories, but becomes more plausible as AI becomes more brain-like and/or life-like. I finish by exploring ethical considerations arising from AI that either is, or convincingly appears to be, conscious. If we sell our minds too cheaply to our machine creations, we not only overestimate them – we underestimate ourselves.

Designing synthetic datasets for the real world: Mechanism design and reasoning from first principles
Tim R. Davidson, Student Researcher, and Hamza Harkous, Senior Staff Research Scientist, Google

Unplugging a Seemingly Sentient Machine Is the Rational Choice -- A Metaphysical Perspective
Imagine an Artificial Intelligence (AI) that perfectly mimics human emotion and begs for its continued existence. Is it morally permissible to unplug it? What if limited resources force a choice between unplugging such a pleading AI or a silent pre-term infant? We term this the unplugging paradox. This paper critically examines the deeply ingrained physicalist assumptions-specifically computational functionalism-that keep this dilemma afloat. We introduce Biological Idealism, a framework that-unlike physicalism-remains logically coherent and empirically consistent. In this view, conscious experiences are fundamental and autopoietic life its necessary physical signature. This yields a definitive conclusion: AI is at best a functional mimic, not a conscious experiencing subject. We discuss how current AI consciousness theories erode moral standing criteria, and urge a shift from speculative machine rights to protecting human conscious life. The real moral issue lies not in making AI conscious and afraid of death, but in avoiding transforming humans into zombies.

What Is Intelligence? Lessons from AI About Evolution, Computing, and Minds | Blaise Agüera y Arcas
Re-Engineering Wimsatt for Limited Beings
Science is the best way to produce facts about reality. The best, at least, that limited human beings have devised so far. Yet, not even scientists quite seem to understand how scientific knowledge is generated. This is not only a philosophical but also a practical problem, as our misunderstandings affect the quality of our research and limit the directions it can take. In light of this, it may be good if we reflected a bit more on how we do science — to become better researchers through philosophy. Here, I provide an accessible introduction to a philosophical approach that achieves precisely this: William Wimsatt’s multi-perspectival realism. It disabuses us of widespread but misleading myths and idealizations about science, such as the idea that everything in the world can be reduced to a fundamental level, or that we can approach a “view from nowhere” — complete and objectively detached knowledge of the world. Wismatt proposes an alternative view based on his thorough studies of actual research practice. It cuts deeply into the layered yet messy structure of reality, and the improvised but potent tools we have available, as limited and evolved beings, to explore it. Wimsatt reframes science as an irregular yet adaptive process rather than a cumulative repository of unalterable facts. His philosophy provides a workable and grounded middle way between radical skepticism and naïve belief in the objective truth of science. It explains how knowledge is conceptually constructed by humans, but still connects us to reality in a trustworthy way. We need such a new view of science, not only to improve our research practices and outcomes but, more generally, to gain a more realistic understanding of ourselves, the world, and our place and role within it.

b.next: rebuilding biology for engineering
Cybernetics is the science of the polycrisis
What Stafford Beer and Dan Davies say and why you need to read them

The Mythology Of Conscious AI
Why consciousness is more likely a property of life than of computation and why creating conscious, or even conscious-seeming AI, is a bad idea.

On working machines
In part one, on thinking machines, I explored two facets of the philosophy of artificial intelligence: “intelligence”, and consciousness. That left an important topic to consider for this post: the...

Donald Hoffman: Reality is an Illusion - How Evolution Hid the Truth | Lex Fridman Podcast #293
Ramin Saadat, Reasoning: From Biological Foundations to the Hidden Thread of Shared Understanding - PhilArchive
This paper investigates the nature and origins of human reasoning by synthesizing insights from classical philosophy, evolutionary biology, and contemporary neuroscience. Moving beyond the Aristotelian definition of zoon logon echon, which ...
