







Human brain architecture is guiding brain-inspired artificial intelligence (AI) and has been treated as an optimal template, whose deviations could mark different psychiatric and neurological conditions. We argue this premise is wrong: under any single goal (e.g., minimal wiring cost or maximal communication efficiency), the human connectome is suboptimal. Instead, its organization reflects multi-objective trade-offs navigated over evolution and development under biological and environmental constraints. For psychopathology, atypical trajectories are not distances from an ideal brain but reweighted compromises in the same trade-off space. For neuro-AI, directly duplicating the brain’s connectivity risks copying its irrelevant compromises. Treating brains and models as products of multi-objective optimization and co-tuning relevant objectives offers a more powerful framework for interpreting clinical phenotypes and designing next-generation AI.
The Global Brain Algorithm
<p>This is a collection of explanations on the global brain algorithm. We explain core concepts in simple terms that help to understand the algorithms as a whole.</p>
How AI coding is reshaping theoretical neuroscience
Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Neuroscientists weigh in on that tectonic change.

Neuropeek — Accelerating the Neuro-AI convergence
Where brain data becomes shared knowledge. A community-driven platform federating neuroscience datasets, models, and tools to accelerate discovery.

The brain in the machine: How AI could help explain how we think | IBM
Scientists are using large AI models to predict patterns of brain activity at scale, a development that researchers say is pushing neuroscience toward a new kind of digital imaging.

The Umwelt Representation Hypothesis: rethinking Universality
Recent studies reveal striking representational alignment between artificial neural networks (ANNs) and biological brains, leading to proposals that all sufficiently capable systems converge on universal representations of reality. We argue that this claim of Universality is premature. We introduce the Umwelt Representation Hypothesis, which proposes that alignment arises not from convergence toward a single global optimum but from overlap in the ecological constraints under which systems develop. We review empirical evidence showing that representational differences between species, individuals, and ANNs are systematic and adaptive, which is difficult to reconcile with Universality. Finally, we reframe ANN model comparison as a method for mapping clusters of alignment in the ecological constraint space rather than as a search for a single optimal world model.

The Global Brain Argument: Nodes, Computroniums and the Ai Megasystem (Target Paper for Special Issue)
The Global Brain Argument contends that many of us are, or will be, part of a global brain network that includes both biological and artificial intelligences (AIs), such as generative AIs ...

Cognition all the way down 2.0: neuroscience beyond neurons in the diverse intelligence era
This paper formalizes biological intelligence as search efficiency in multi-scale problem spaces, aiming to resolve epistemic deadlocks in the basal “cognition wars” unfolding in the Diverse Intelligence research program. It extends classical work on symbolic problem-solving to define a novel problem space lexicon and search efficiency metric. Construed as an operationalization of intelligence, this metric is the decimal logarithm of the ratio between the cost of a random walk and that of a biological agent. Thus, the search efficiency measures how many orders of magnitude of dissipative work an agentic policy saves relative to a maximal-entropy search strategy. Empirical models for amoeboid chemotaxis and barium-induced planarian head regeneration show that, under conservative (i.e., intelligence-underestimating) assumptions, even ‘simple’ organisms are from two-hundred- to sextillion-fold more efficient in problem space exploration. In this sense, the deep insights of neuroscience are not about neurons per se, but about the policies and patterns of physics and mathematics that function as a kind of “cognitive glue” binding parts toward higher levels of collective intelligence in wholes of highly diverse composition and origin. Therefore, our synthesis argues that the “mark of the cognitive” is perhaps better sought in the measurable efficiency with which living systems, from single cells to complex organisms, traverse energy and information gradients to tame combinatorial explosions-one problem space at a time.

AI overuse could spark "brain fry," new research finds
The mental strain associated with AI carries "significant costs," researchers find.

Inventing the future: A neuroscience research roadmap
The past decade of transformative advances in neurotechnology portends an exciting future for neuroscience. This NeuroView charts a strategic path to accelerate and integrate research discovery and speed the development of new cures for human brain disorders.

Introducing TRIBE v2: A Predictive Foundation Model Trained to Understand How the Human Brain Processes Complex Stimuli
Understanding how the human brain processes the world around us is one of the greatest open challenges in neuroscience. Breakthroughs here could transform how we understand and treat neurological conditions affecting hundreds of millions of people — and improve AI systems by directly guiding their development from neuroscientific principles.

Scaling Managed Agents: Decoupling the brain from the hands
Anthropic is an AI safety and research company that's working to build reliable, interpretable, and steerable AI systems.

GitHub - AIM-KannLab/BrainIAC | Giovanni Giulietti
One of the biggest hurdles in neuroimaging AI has always been the scarcity of labeled data, especially for rare conditions. But a recent study published in Nature Neuroscience introduces a potential solution: BrainIAC (Brain Imaging Adaptive Core). Unlike traditional models that are trained for one specific task, BrainIAC is a "foundation model", a large-scale AI model trained on vast amounts of data that can perform many different tasks and be adapted to specific applications. It was pretrained on a massive dataset of 48965 brain structural MRI sequences (T1w, T2w, FLAIR, T1CE) using self-supervised learning, allowing it to understand the "big picture" of brain anatomy across different ages and conditions. It has been tested across seven diverse and clinically meaningful applications: - brain age prediction - IDH mutation classification - Mild Cognitive Impairment (MCI) classification - diffuse glioma overall survival prediction - MR sequence classification - time-to-stroke prediction - tumor segmentation BrainIAC consistently outperformed traditional supervised learning approaches and other medical-specific models. The real "magic" happens in low-data scenarios. While traditional AI usually needs thousands of examples, BrainIAC can adapt to new tasks using only a few samples. BrainIAC can be used for structural brain MRI analysis through two main methods: - Web Usage (BrainIAC platform): the easiest way to use BrainIAC, providing a user-friendly interface to upload structural brain MRI data and run inference. - Local usage (GitHub repository): for more advanced and customized analysis. It allows complete control over the data preprocessing, model training, and inference pipelines. It requires Python 3.9+ and NVIDIA GPU with CUDA 11.0+. 🔗 BrainIAC paper: https://lnkd.in/dq6Gprgt 🔗 BrainIAC web platform https://lnkd.in/dpreadMp 🔗 BrainIAC GitHub repo: https://lnkd.in/duwSEg4V #MedicalAI #Neuroscience #HealthTech #BrainIAC #Radiology #Innovation #DeepLearning #PrecisionMedicine
The Fabric and the Brain
Articulating agent ecologies with high-personality planetary computation


NeuroAI
Neuroscience, cognitive science, and AI are all questing for principles that help generalization. Learn more through a live, synchronous program designed for focused, hands-on learning.
1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social biorxiv.org/content/10.1101/2025.11.12.68…
Characterizing neuronal population geometry with AI equation discovery
www.biorxiv.org