Video-gamers have co-authored a paper describing a new set of rules for determining the difficulty of designing structures composed of RNA molecules.
The Multiple Paths to Multiple Life
We argue for multiple forms of life realized through multiple different historical pathways. From this perspective, there have been multiple origins of life on Earth—life is not a universal homology. By broadening the class of originations, we significantly expand the data set for searching for life. Through a computational analogy, the origin of life describes both the origin of hardware (physical substrate) and software (evolved function). Like all information-processing systems, adaptive systems possess a nested hierarchy of levels, a level of function optimization (e.g., fitness maximization), a level of constraints (e.g., energy requirements), and a level of materials (e.g., DNA or RNA genome and cells). The functions essential to life are realized by different substrates with different efficiencies. The functional level allows us to identify multiple origins of life by searching for key principles of optimization in different material form, including the prebiotic origin of proto-cells, the emergence of culture, economic, and legal institutions, and the reproduction of software agents.
AI-designed nucleases build on nature’s design
Researchers used AI to create variants of a CRISPR-Cas12-like nuclease, some of which show increased editing activity
The Video Game Library | All Books on Videogames
The Video Game Library is a site that celebrates books about videogames. From artbooks and children's books to novelizations and biographies. Indie writers to best-selling authors. Atari to Xbox. Come have a look and discover some books.
How Life Works: A User’s Guide to the New Biology
“Bold and intriguing.”—Wall Street Journal • “Penetrating. . . . Provocative and profound.”—Publishers Weekly (starred review) • “Offers plenty of food for thought.”—Kirkus Reviews (starred review) “Ball’s marvelous book is both wide-ranging and deep. . . . I could not put it down.”—Siddhartha Mukherjee, author of The Song of the Cell and the Pulitzer Prize–winning The Emperor of All Maladies A new, cutting-edge vision of biology that revises our understanding of what life itself is, how to enhance it, and what possibilities it offers. Biology is undergoing a quiet but profound transformation. Several aspects of the standard picture of how life works—the idea of the genome as a blueprint, of genes as instructions for building an organism, of proteins as precisely tailored molecular machines, of cells as entities with fixed identities, and more—have been exposed as incomplete, misleading, or wrong. In How Life Works, Philip Ball explores the new biology, revealing life to be a far richer, more ingenious affair than we had guessed. Ball explains that there is no unique place to look for an answer to this question: life is a system of many levels—genes, proteins, cells, tissues, and body modules such as the immune system and the nervous system—each with its own rules and principles. How Life Works explains how these levels operate, interface, and work together (most of the time). With this knowledge come new possibilities. Today we can redesign and reconfigure living systems, tissues, and organisms. We can reprogram cells, for instance, to carry out new tasks and grow into structures not seen in the natural world. As we discover the conditions that dictate the forms into which cells organize themselves, our ability to guide and select the outcomes becomes ever more extraordinary. Some researchers believe that ultimately we will be able to regenerate limbs and organs, and perhaps even create new life forms that evolution has never imagined. Incorporating the latest research and insights, How Life Works is a sweeping journey into this new frontier of the life sciences, a realm that will reshape our understanding of life as we know it.
README.md · Motif-Technologies/Motif-3-Beta at 32b030593c716a9bb860731baeef2925aaaaaf3a
We’re on a journey to advance and democratize artificial intelligence through open source and open science.
Motif-Technologies/Motif-3-Beta · Hugging Face
We’re on a journey to advance and democratize artificial intelligence through open source and open science.
Biohub releases a world model of protein biology
Open AI models used for a wide range of scientific applications, including accelerating the design of therapeutic molecules.
Game Dev by @trezy.codes
Posts about all aspects of game development. Opt in with "game", followed by animation, art, audio, design, dev, jam, lighting, music, narrative, or writing. Opt out with #Private, #NoFeed, or #NoGameDev. Discuss at trezy.studio/discord. Support the feed at ko-fi.com/trezycodes.
Game Dev by @trezy.codes
Posts about all aspects of game development. Opt in with "game", followed by animation, art, audio, design, dev, jam, lighting, music, narrative, or writing. Opt out with #Private, #NoFeed, or #NoGameDev. Discuss at trezy.studio/discord. Support the feed at ko-fi.com/trezycodes.
Motif-Technologies/Motif-3-Beta at 32b030593c716a9bb860731baeef2925aaaaaf3a
We’re on a journey to advance and democratize artificial intelligence through open source and open science.
gamesgamesgamesgamesgames/lexicon
An open data standard for describing video games and their data on ATProto.
AI creates first synthetic viruses
Genomic language model has huge potential to redesign organisms such as bacteria
Molecular Biology in the Work of Deleuze and Guattari
This article looks at Deleuze and Guattari's understanding of molecular biology, focusing particularly on their reading of two highly influential works by the eminent French molecular biologists François Jacob and Jacques Monod, La logique du vivant (The Logic of Living Systems) and Le hasard et la nécessité (Chance and Necessity). In these two works, Jacob and Monod present the significance of molecular biology in broadly reductionist terms. What is more, the lac operon model of gene regulation that they propose serves to reinforce the so-called Central Dogma of molecular biology, according to which information passes from DNA to RNA to proteins, with no reverse route. However, Deleuze and Guattari discover intensive potentials within the descriptions of molecular biology offered by both writers. It is argued that Jacob's work in particular, as it has developed in the years since the publication of La logique du vivant in 1970, has itself developed these intensive potentials.
Designing RNA sequencing experiments: A practical guide to reproducible gene expression analysis
RNA sequencing (RNA-seq) has become a cornerstone of modern biotechnology, offering a comprehensive and high-resolution view of gene expression that enables the discovery of novel transcripts across diverse biological systems. Its applications extend beyond basic transcriptomics, providing powerful tools for uncovering molecular mechanisms underlying disease, environmental responses, and chemical toxicity. In biotechnology and biomedical research, RNA-seq facilitates the identification of regulatory networks and biomarkers that inform therapeutic development, risk assessment, and precision medicine.
If the DNA molecule is the book of life, it's a very strange book indeed - 3 Quarks Daily
by Yohan J. John