Introducing Hypothesis commenting on bioRxiv and medRxiv: an updated way to engage with preprints - openRxiv

Launching openRxiv Labs - openRxiv

Over the last thirteen years, bioRxiv and medRxiv have grown into widely used infrastructure for rapid research sharing in biology and medicine. The reliability and researcher-first values that have defined these platforms since their founding remain central to how we operate, and building on the trust, partnerships, and community relationships researchers worldwide depend on is…

Homepage - openRxiv

openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.

The Story behind the Science: Preprints of pandemic potential—how bioRxiv and medRxiv brought preprints to the life sciences

ABSTRACT The bioRxiv and medRxiv preprint servers brought preprinting to the life sciences and played a critical role in disseminating COVID research during the pandemic. Here, I reflect on the birth of bioRxiv and medRxiv and the crucial role so many members of the community played, our experience during the pandemic, and the launch of the new non-profit organization set up to oversee the servers. The pandemic was a stress test for bioRxiv and medRxiv that demonstrated their value and robustness. Under the umbrella of openRxiv, they are now poised to become long-term infrastructure underpinning a new publishing ecosystem.

Curvenote Reader brings a better reading experience to half a million openRxiv preprints

Curvenote Reader is now live across half a million bioRxiv preprints - bringing inline citations, zoomable figures, and connected context directly into the reading flow. Find out how we modernized one of science's biggest preprint repositories without disrupting a single workflow.

Center for Open Science

At the Center for Open Science, our mission is to increase openness, integrity, and reproducibility of scholarly research. Promoting these practices within the research funding and publishing communities accelerates scientific progress

OpenRxiv & Curvenote’s new Reader launch took to the stage at FORCE11 2026

At FORCE11 2026, Curvenote showcased the newly launched Curvenote Reader deployed over all of openRxiv to enthusiastic feedback from scientific publishing leaders — with callouts on the innovation from the opening and closing keynotes as a meaningful step forward for open science.

The Next Decade of Preprints Needs Experiments, Not Opinions

Lately, I have spent a considerable amount of time writing about my concerns regarding the direction of the preprint ecosystem and the behaviour of some of the actors within it. Increasingly, I wor…

Making sense of preprints by adding context – The Publish Your Reviews initiative - LSE Impact

Improving scientific publishing is often framed as an issue of openness and speed and less often as one of context. In this post, Ludo Waltman and Jessica Polka make the case for a more contextualised approach to open access publishing and preprinting, and introduce the Publish Your Reviews initiative. Launched today by ASAPbio, the initiative

Coordinating Research Assessment And Publishing Reform: Action Groups – ASAPbio

Connect with focused ASAPbio groups working on specific aspects of scientific communication, from preprint review to community engagement.

We live in a golden age of biology. So why are people still dying from disease? Because discovery and development move slower than they should. Today, we’re partnering with Incyte to change… | Samuel G. Rodriques | 491 comments

We live in a golden age of biology. So why are people still dying from disease? Because discovery and development move slower than they should. Today, we’re partnering with Incyte to change that. Kosmos is now the first agent that can compress months of drug development into weeks, from the earliest stages of scientific discovery through to FDA approval. Incyte will be the first company to deploy it across their pipeline. Work that used to take a team of scientists months now happens in weeks. Patients can't wait, and neither can we. | 491 comments on LinkedIn

Why we’re expanding the openRxiv Labs Curvenote Reader experiment

Read on for early results and what we’ll be looking at in the next phase.

Assessing and mitigating batch effects in large-scale omics studies

Batch effects in omics data are notoriously common technical variations unrelated to study objectives, and may result in misleading outcomes if uncorrected, or hinder biomedical discovery if over-corrected. Assessing and mitigating batch effects is crucial for ensuring the reliability and reproducibility of omics data and minimizing the impact of technical variations on biological interpretation. In this review, we highlight the profound negative impact of batch effects and the urgent need to address this challenging problem in large-scale omics studies. We summarize potential sources of batch effects, current progress in evaluating and correcting them, and consortium efforts aiming to tackle them.