Fact Sheet 2: Post-exertional malaise (PEM)

Post-exertional malaise (PEM) in ME/CFS

Post-exertional malaise (PEM), the cardinal feature of ME/CFS, is particularly debilitating as it involves the amplification of existing symptoms, alongside the potential appearance of new ones, following minimal exertion. However, the term “exertion” may be misconstrued, by those unfamiliar with ME/CFS, as activities typically considered high intensity by healthy individuals. Consequently, healthy individuals may inappropriately…

STAT

Reporting from the frontiers of health and medicine

Canicule et mortalité : logements, inégalités sociales et hôpitaux en tension, ces enjeux essentiels mis de côté

ANALYSE. Le gouvernement axe sa communication sur des mesures comportementales individuelles, de prévention ou de vigilance, mais ne met pas l’accent sur un certain nombre de questions centrales, si l’on veut lutter contre les effets sanitaires les plus graves.

Who listens when mental health struggles disrupt daily life?

Ask a Bangladeshi newspaper reader to picture a mental health story. Perhaps a psychiatrist’s quote comes to mind, a helpline number, or a headline about a student’s death.

Burnout Phase Transition - meri's missives

Modelling chronic stress effects on my mental health and the end of monopolies

Laziness Does Not Exist

Psychological research is clear: when people procrastinate, there's usually a good reason

Fact Sheet 3: ME/CFS: Information for Medical Professionals

Fact Sheet 3: ME/CFS: Information for Medical Professionals Published December 2025 Link to pdf: ME/CFS: Information for Medical Professionals.pdf Discussion thread: Fact sheet #3: Information...

When one can work no more: The effects of burnout on your body

Continual stress is often associated with emotional problems, but it can also have major physical consequences, including heart attacks

Césure et interruption pendant les études

Le Céreq publie les résultats d'une étude inédite sur l'impact de ces interruptions sur l'insertion professionnelle des jeunes diplômés.

Patient-reported treatment outcomes in ME/CFS and long COVID

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are persistent multisystem illnesses affecting many patients. With no known effective FDA-approved treatments for either condition, patient-reported outcomes of treatments may prove helpful in identifying management strategies that can improve patient care and generate new avenues for research. Here, we present the results of an ME/CFS and long COVID treatment survey with responses from 3,925 patients. We assess the experiences of these patients with more than 150 treatments in conjunction with their demographics, symptoms, and comorbidities. Treatments with the greatest perceived benefits are identified. Patients with each condition who participated in the study shared similar symptom profiles, including all the core symptoms of ME/CFS, e.g., 89.7% of ME/CFS and 79.4% of long COVID reported postexertional malaise (PEM). Furthermore, treatment responses between these two patient groups were significantly correlated (R 2 = 0.68). Patient subgroups, characterized by distinct symptom profiles and comorbidities, exhibited increased responses to specific treatments, e.g., a POTS-dominant cluster benefiting from autonomic modulators and a cognitive-dysfunction cluster from CNS stimulants. This study underscores the symptomatic and therapeutic similarities between ME/CFS and long COVID and highlights the commonalities and nuanced complexities of infection-associated chronic diseases and related conditions. While this study does not provide recommendations for specific therapies, in the absence of approved treatments, insights from patient-reported experiences provide urgently needed real-world evidence for developing targeted patient care therapies and future clinical trials.

"Opposer le monde virtuel au monde réel est une erreur" : la réponse de Séverine Erhel à Jonathan Haidt

La chercheuse en psychologie cognitive a apprécié le best-seller "Génération anxieuse" de Jonathan Haidt. Mais elle critique le lien que fait son auteur entre suicide ou dépression chez les mineurs et réseaux sociaux.

Four Months Later, My Head Is Quiet - Ewan’s Blog

I didn’t realise how much of my baseline was illness until parts of it disappeared.

Open Source Burnout Claims Another Project

Yet another OSS maintainer quits because of burnout. To fix this, we need better mental health resources for maintainers.

Une «blessure invisible» : un an après l’incendie à Marseille, la lente reconstruction psychologique des victimes — Vert

Alors que d’importants feux font rage dans le sud de la France depuis plusieurs jours, Vert est allé à la rencontre de victimes d’un incendie dans le nord de Marseille survenu en 2025. Il y a un an jour pour jour, les habitant·es du quartier de l'Estaque ont vu 750…

Eradicating Unhappiness

Is there a manual for living well? Where modern science, society, and psychology underserves, a philosophy nearly as old as time emerges. “Take a simple idea, and take it seriously.”—Charlie Munger…