The Sick Times - Chronicling the Long COVID crisis

annotations: La crise du Covid-19 exacerbe les injustices au travail

Blog de sciences économiques et sociales de Martin Anota. Traductions, revues de presse.

Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID

Viral and infectious illnesses can exert profound and enduring effects on population health and well-being. In the aftermath of SARS-CoV-2 infection, post-acute sequelae, collectively referred to as Long COVID, have emerged as a major global health challenge, affecting more than 400 million people and contributing to estimated annual economic costs exceeding $1 trillion. Long COVID encompasses a wide and heterogeneous spectrum of debilitating symptoms, including cognitive dysfunction, sleep disturbances, severe fatigue, and post-exertional malaise. Despite its substantial burden, fundamental uncertainties remain regarding its underlying pathophysiology, the development of robust diagnostic criteria, and the identification of effective therapeutic options. This review synthesises current evidence on the biological mechanisms thought to contribute to Long COVID, spanning immune dysregulation, viral persistence, autonomic dysfunction, microvascular pathology, and other emerging hypotheses. We examine advances and limitations in contemporary diagnostic approaches and critically appraise existing treatment strategies, highlighting inconsistencies and gaps that hinder clinical consensus. By integrating interdisciplinary insights, this review underscores the urgent need for mechanistic clarity, validated diagnostic frameworks, and rigorously evaluated treatment pathways. Addressing these gaps will be essential to developing effective, evidence-based management strategies and mitigating the long-term impact of Long COVID on global health.

Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID

Viral and infectious illnesses can exert profound and enduring effects on population health and well-being. In the aftermath of SARS-CoV-2 infection, post-acute sequelae, collectively referred to as Long COVID, have emerged as a major global health challenge, affecting more than 400 million people and contributing to estimated annual economic costs exceeding $1 trillion. Long COVID encompasses a wide and heterogeneous spectrum of debilitating symptoms, including cognitive dysfunction, sleep disturbances, severe fatigue, and post-exertional malaise. Despite its substantial burden, fundamental uncertainties remain regarding its underlying pathophysiology, the development of robust diagnostic criteria, and the identification of effective therapeutic options. This review synthesises current evidence on the biological mechanisms thought to contribute to Long COVID, spanning immune dysregulation, viral persistence, autonomic dysfunction, microvascular pathology, and other emerging hypotheses. We examine advances and limitations in contemporary diagnostic approaches and critically appraise existing treatment strategies, highlighting inconsistencies and gaps that hinder clinical consensus. By integrating interdisciplinary insights, this review underscores the urgent need for mechanistic clarity, validated diagnostic frameworks, and rigorously evaluated treatment pathways. Addressing these gaps will be essential to developing effective, evidence-based management strategies and mitigating the long-term impact of Long COVID on global health.

Evidence mounts that Long Covid is damaging the hearts of those affected

There are also increasing signs that the condition can disrupt the autonomic nervous system

Opinion | When It Comes to Covid-19, Most of Us Have Risk Exactly Backward (Published 2020)

We aren’t very good at discussing trade-offs, but we need to make some during this pandemic.

Archive: New COVID-19 ‘Citizen Science’ Initiative Lets Any Adult with a Smartphone Help to Fight Coronavirus

The online study would try to help researchers gain insight into how the virus is spreading and identify ways to predict and reduce the number of new infections.

Researchers link Long COVID to another virus | NHK WORLD-JAPAN News

Researchers in Japan have released findings showing that COVID-19 after effects, including fatigue, occur when a coronavirus infection activates another virus already inside the body.

annotations: Le Covid-19 et la nouvelle bataille des idées en Europe

Blog de sciences économiques et sociales de Martin Anota. Traductions, revues de presse.

COVID antihistamine protocol

This current wave of COVID is bad, and I'm seeing a lot of people who were previously NOVID posting photos of their positive tests. I've been trying fairly diligently to get this information out on social media, because I know I follow the literature a lot more closely than a lot of people, so here

Patient Led Research Collaborative  for Long COVID

About the Patient-Generated Hypotheses JournalPatient-Led Research Collaborative

Patient Led Research Collaborative  for Long COVID

About the Patient-Generated Hypotheses JournalPatient-Led Research Collaborative

Underlying Conditions and the Higher Risk for Severe COVID-19

Learn risk factors for severe outcomes from COVID-19 and actions to take.

Meta to roll back Covid-19 misinformation measures

Meta is revising its policies to take a regional approach towards countries that still have public health emergency declarations.

Homebound: The Long-Term Rise in Time Spent at Home Among U.S. Adults

The changes in daily life induced by the COVID-19 pandemic brought renewed attention to longstanding concerns about social isolation in the United States. Despite the links between the physical setting for individuals' daily lives and their connections with family, friends, and the various institutions of collective life, trends in where American adults spend their time have been largely overlooked as researchers have focused on how and with whom they spend their time. This article analyzes data from the American Time Use Survey over a timeframe spanning nineteen years and argues that the changes in Americans' daily routines induced by the COVID era should be seen as an acceleration of a longer-term trend: the rise of time spent at home. Results show that from 2003 to 2022, average time spent at home among American adults has risen by one hour and 39 minutes in a typical day. Time at home has risen for every subset of the population and for virtually all activities. Preliminary analysis indicates that time at home is associated with lower levels of happiness and less meaning, suggesting the need for enhanced empirical attention to this major shift in the setting of American life.