







In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain.
Dopamine Fracking
The act of pumping immense, disproportionate resources into a previously casual or complex and layered activity to forcefully extract and squeeze out the purest, most concentrated dopamine hit
Introducing The Psyche Network
Who Gets to Define Human Suffering?
As psychiatry concedes long-standing criticisms of diagnosis, a deeper question emerges: What now justifies its authority over human suffering?

Dopamine Trap
Dopamine Trap does narrative driven decay. With organic noise, apocalyptic soundscapes, and scathing poetry his productions cast lovecraftian solopsisms on the roof of the skull, dripping with tumors of unresolved inter-generational trauma, resignation and reckless, violent love. He delights in emptiness and the granular implications of percussive silence.
How tiny experiments can set you free | Anne-Laure Le Cunff | TEDxNashville | Transcript
When Dr Anne-Laure Le Cunff was told she might die, her first instinct was to check her calendar. In this talk, she reveals how our desperate need for control keeps us stuck and how tiny experiments can set us free. Dr Anne-Laure Le Cunff is a neuroscientist, author, and entrepreneur who studies curiosity – both in the lab and in life. Her research at King’s College London explores how our brains seek, learn, and adapt, spanning areas from ADHD to AI and mental health. She founded Ness Labs, a science-based learning platform helping people live more experimental lives. Her bestselling book Tiny Experiments offers a practical guide to transforming uncertainty into curiosity, creativity, and self-discovery. Through her research and writing, she bridges science and everyday life, showing how curiosity can help us loosen control, embrace change, and uncover who we truly are.

Life Forms with Music: On Susie Ibarra — United States Artists
Anne Ishii on Susie Ibarra's impactful practice
AI Needs to Feel Pain
Leading Innovation in Psychiatric Treatment | Alto Neuroscience
We leverage brain biology to develop personalized medicines, helping patients get better faster.

Computational Psychiatry Needs Systems Neuroscience
This piece was originally published in The Transmitter. I am adapting it here with some additional context for readers of this newsletter.

Doris Tsao
Doris Tsao is the Chief Scientist for Neuro at Astera. Previously, she was a professor at UC Berkeley in the Neuroscience Department.

UCLA discovers first stroke rehabilitation drug to repair brain damage
A new study by UCLA Health has discovered what researchers say is the first drug to fully reproduce the effects of physical stroke rehabilitation in model mice.

Psychiatry at the Margins | Awais Aftab | Substack
Exploring critical, philosophical, and scientific debates in psychiatric practice and the psy-sciences. Click to read Psychiatry at the Margins, by Awais Aftab, a Substack publication with tens of thousands of subscribers.

NeuroNYC
As the global leader in finance, policy, art, research, and medicine, the region is well-positioned to lead neurotech. We help foster and promote the local neurotech ecosystem: clinics, companies, funders, labs, and users.

Blueprint Neurotech
The Center for Innovative NeuroTech Advancement (CINTA) & NeuroTech Harbor (NTH) announce the Cycle 6 Award Competition supported by the NIH Blueprint MedTech Program. This program is seeking collaborative projects aimed at developing emerging technologies into commercially viable, clinically focused solutions for disorders of the nervous system that are aligned with the mission and interests of the participating NIH institutes and centers.
The Psychopathic Selection Hypothesis: The Rules of the Game Keep Us Trapped - The Great Simplification
In this episode, Nate is joined by Greg Elliott, a systems theorist and author of the Psychopathic Selection Hypothesis (PSH), to unpack why our institutions themselves have become so psychopathic, and how that affects the behavior of the average human.
#777: Happily surrendering our leisure to lines
Plus: the physicality of data, the second coming of froyo, and the rise of "dopamine sites"
