AI holds promise for transforming scientific processes, including hypothesis generation. Prior work on hypothesis generation can be broadly categorized into theory-driven and data-driven approaches. While both have proven effective in generating novel and plausible hypotheses, it remains an open question whether they can complement each other. To address this, we develop the first method that combines literature-based insights with data to perform LLM-powered hypothesis generation. We apply our method on five different datasets and demonstrate that integrating literature and data outperforms other baselines (8.97\% over few-shot, 15.75\% over literature-based alone, and 3.37\% over data-driven alone). Additionally, we conduct the first human evaluation to assess the utility of LLM-generated hypotheses in assisting human decision-making on two challenging tasks: deception detection and AI generated content detection. Our results show that human accuracy improves significantly by 7.44\% and 14.19\% on these tasks, respectively. These findings suggest that integrating literature-based and data-driven approaches provides a comprehensive and nuanced framework for hypothesis generation and could open new avenues for scientific inquiry.
Can AI Agents Synthesize Scientific Conclusions?
Scientific AI agents increasingly retrieve evidence, reason across sources, and synthesize conclusions used in consequential decisions. Yet, their ability to do so in high-stakes domains such as health remains unclear. We introduce SciConBench, a large-scale live benchmark of 9.11K questions and expert-written conclusions from systematic reviews to evaluate open-domain scientific conclusion synthesis. The benchmark draws on an expert-validated automated evaluation pipeline that decomposes conclusions into atomic facts and measures correctness and comprehensiveness via factual precision and recall. To mitigate data leakage, we further introduce SciConHarness, a clean-room evaluation harness that equips agents with controlled web interaction to ensure valid measurement. Evaluating 8 frontier models and deep research agents, we find that factual quality remains low: under clean-room settings, the best agent achieves only a factual F1 of 0.337. Our clean-room setting consistently reduces performance relative to unconstrained evaluation, suggesting that leakage inflates estimates of models' true synthesis capabilities. Finally, we audit consumer-facing agents (e.g., Google AI Overview, OpenEvidence) and find they frequently generate incomplete and sometimes contradictory conclusions, even when the ground-truth answer is available. Overall, our results show that reliable synthesis of scientific conclusions remains an open challenge, and that clean-room evaluation is essential for assessing open-domain AI agents.
ScientistTwo: Pioneering the Human Knowledge Frontier with Autonomous AI
Scientific discovery is defined by the ability to identify the boundaries of existing knowledge and venture into unexplored territory. The ultimate vision for AI in science is problem-driven autonomous research: given a fundamental challenge by a human expert, the AI independently navigates the scientific landscape, uncovers theoretical and empirical bottlenecks, and systematically expands the frontier of knowledge. In this paper, we introduce ScientistTwo, a fully autonomous multi-agent framework designed to realize this vision. Specifically, ScientistTwo takes an initial problem as input, establishes state-of-the-art baselines, formulates novel hypotheses, and coordinates specialized agents to orchestrate an end-to-end discovery cycle without human intervention. Moreover, the framework rigorously conducts experiments using diverse datasets and metrics, refines methodologies through automated ablation studies, and validates research findings via a closed-loop simulated peer-review rebuttal engine. To evaluate ScientistTwo's capabilities against the highest standards of human scientific achievement, we benchmark it across papers accepted at top-tier conferences such as ICLR, ICML, and NeurIPS. As a result, ScientistTwo autonomously generates expert-level, publishable papers and fully verified, executable codebases. Its solutions consistently outperform human state-of-the-art models, and achieve higher average review ratings than human-authored papers under automated AI review agents. These results show that ScientistTwo is not merely an assistive tool but an autonomous scientific pioneer capable of pushing the frontiers of human discovery. Project website: https://scientist-two.github.io/
Sparse Autoencoders for Hypothesis Generation
We describe HypotheSAEs, a general method to hypothesize interpretable relationships between text data (e.g., headlines) and a target variable (e.g., clicks). HypotheSAEs has three steps: (1) train a sparse autoencoder on text embeddings to produce interpretable features describing the data distribution, (2) select features that predict the target variable, and (3) generate a natural language interpretation of each feature (e.g., "mentions being surprised or shocked") using an LLM. Each interpretation serves as a hypothesis about what predicts the target variable. Compared to baselines, our method better identifies reference hypotheses on synthetic datasets (at least +0.06 in F1) and produces more predictive hypotheses on real datasets (~twice as many significant findings), despite requiring 1-2 orders of magnitude less compute than recent LLM-based methods. HypotheSAEs also produces novel discoveries on two well-studied tasks: explaining partisan differences in Congressional speeches and identifying drivers of engagement with online headlines.
Verification in the Age of AI Scientists
AI Scientists now operate at a scale that outpaces human capacity for manual review. Systems such as Sakana’s AI Scientist write entire workshop papers end-to-end. Lila Sciences runs autonomous ``AI Science Factories’’ that hypothesize, experiment, and iterate without human guidance. FutureHouse’s Kosmos and Robin generate thousands of candidate hypotheses in a single run, and Google’s Co-Scientist proposes testable experiments at a rate no laboratory can fully evaluate. Each of these systems emphasizes verified results, yet that standard ranges from near-perfect formal proof in mathematics to decade-long clinical trials in medicine, with no shared framework for judging sufficiency across domains. As outputs scale beyond what humans can manually inspect, the question of which results to trust becomes as hard as generating them. The bottleneck for AI for Science is no longer hypothesis generation, it is verification.
Language agents achieve superhuman synthesis of scientific knowledge
Language models are known to hallucinate incorrect information, and it is unclear if they are sufficiently accurate and reliable for use in scientific research. We developed a rigorous human-AI comparison methodology to evaluate language model agents on real-world literature search tasks covering information retrieval, summarization, and contradiction detection tasks. We show that PaperQA2, a frontier language model agent optimized for improved factuality, matches or exceeds subject matter expert performance on three realistic literature research tasks without any restrictions on humans (i.e., full access to internet, search tools, and time). PaperQA2 writes cited, Wikipedia-style summaries of scientific topics that are significantly more accurate than existing, human-written Wikipedia articles. We also introduce a hard benchmark for scientific literature research called LitQA2 that guided design of PaperQA2, leading to it exceeding human performance. Finally, we apply PaperQA2 to identify contradictions within the scientific literature, an important scientific task that is challenging for humans. PaperQA2 identifies 2.34 +/- 1.99 contradictions per paper in a random subset of biology papers, of which 70% are validated by human experts. These results demonstrate that language model agents are now capable of exceeding domain experts across meaningful tasks on scientific literature.
AI Research Agents Narrow Scientific Exploration
AI research agents now support large-scale AI-assisted scientific discovery. We examine whether AI-generated ideas broaden scientific exploration or primarily reinforce existing work. Using five agent frameworks and five large language models, we generate 219,655 ideas for different scientific fields. Across experiments, four consistent patterns emerge. First, AI-generated ideas are more concentrated than human-authored papers within the same research area. Second, they remain much closer to starting literature than later human follow-on work does. Third, AI-generated ideas align less with future human research. Last, AI-generated ideas are located in lower-impact regions of the historical scientific landscape. Overall, current AI research agents appear better suited to local elaboration than to broadening scientific exploration.
Accelerating Scientific Research with Gemini: Case Studies and Common Techniques
Recent advances in large language models (LLMs) have opened new avenues for accelerating scientific research. While models are increasingly capable of assisting with routine tasks, their ability to contribute to novel, expert-level mathematical discovery is less understood. We present a collection of case studies demonstrating how researchers have successfully collaborated with advanced AI models, specifically Google's Gemini-based models (in particular Gemini Deep Think and its advanced variants), to solve open problems, refute conjectures, and generate new proofs across diverse areas in theoretical computer science, as well as other areas such as economics, optimization, and physics. Based on these experiences, we extract common techniques for effective human-AI collaboration in theoretical research, such as iterative refinement, problem decomposition, and cross-disciplinary knowledge transfer. While the majority of our results stem from this interactive, conversational methodology, we also highlight specific instances that push beyond standard chat interfaces. These include deploying the model as a rigorous adversarial reviewer to detect subtle flaws in existing proofs, and embedding it within a "neuro-symbolic" loop that autonomously writes and executes code to verify complex derivations. Together, these examples highlight the potential of AI not just as a tool for automation, but as a versatile, genuine partner in the creative process of scientific discovery.
Towards Automating Scientific Review with Google's Paper Assistant Tool
Artificial intelligence is driving a revolution in scientific discovery, accelerating everything from hypothesis generation to mathematical theorem proving. However, this rapid acceleration is creating a systemic challenge: traditional human peer review cannot scale to match the influx of AI-assisted science. Ultimately, to resolve this tension, we must also deploy AI to accelerate the verification and review process itself. To frame the discussion around this transition, we propose a taxonomy consisting of four progressive levels of AI-human collaboration in scientific evaluation, and discuss various trade-offs involved with each. As a step toward this future, we introduce the Paper Assistant Tool (PAT), an agentic AI framework built for deep scientific review and verification. PAT ingests full scientific manuscripts and produces a comprehensive evaluation, checking theoretical results, validating experiments, suggesting improvements, and identifying potential flaws. By utilizing inference scaling techniques, PAT is able to identify deeper issues than a single model call alone, achieving a 34% improvement over zero-shot recall on mathematical errors in the SPOT benchmark. Pilot deployments of PAT as a pre-submission tool for authors at two major Computer Science conferences -- STOC and ICML -- demonstrate its ability to identify critical errors and suggest substantive improvements to research papers. By catching errors early, PAT eases the cognitive burden placed on referees, while preserving their control over the outcomes of the review process.
Words that Work: Using Large Language Models to Generate and Refine Hypotheses from Text
In this paper, we introduce a data-driven framework for generating and refining hypotheses from text. Our three-step approach–Hypothesize, Intervene, and Predic
EXPRESS: Evaluating Novel Unstructured Treatments with Generative AI: A Causal Prediction Framework
Modern marketing increasingly requires managers to deploy new content at scale, often with limited opportunity for prior testing. As a result, decisions about what to launch become strategic managerial choices under uncertainty rather than purely creative exercises. While generative AI makes the creation of new content fast and highly scalable, it simultaneously expands the set of options managers must evaluate, making reliable content selection increasingly difficult. We develop a framework for causal prediction that enables managers to evaluate and deploy novel marketing content generated by AI. The framework uses pretrained large language models to represent previously deployed content and learn how its features causally relate to outcomes. Using a rejection-sampling procedure, the framework screens new content proposed by generative AI to avoid extrapolation beyond what historical data can reliably support. In a large-scale email marketing application (3.3 million observations across 34 campaigns), the framework improves out-of-sample prediction and real-world deployment performance relative to standard approaches, enabling outcome-guided generation of higher-performing AI-generated content. The framework establishes a threshold based on how closely new content resembles past campaigns, separating cases where causal prediction is reliable from cases where direct experimentation is warranted. The framework has important implications for marketing decision making in a rapidly evolving environment where generative AI is transforming content creation and deployment.
Artificial intelligence tools expand scientists’ impact but contract science’s focus
Developments in artificial intelligence (AI) have accelerated scientific discovery1. Alongside recent AI-oriented Nobel prizes2–9, these trends establish the role of AI tools in science10. This advancement raises questions about the influence of AI tools on scientists and science as a whole, and highlights a potential conflict between individual and collective benefits11. To evaluate these questions, we used a pretrained language model to identify AI-augmented research, with an F1-score of 0.875 in validation against expert-labelled data. Using a dataset of 41.3 million research papers across the natural sciences and covering distinct eras of AI, here we show an accelerated adoption of AI tools among scientists and consistent professional advantages associated with AI usage, but a collective narrowing of scientific focus. Scientists who engage in AI-augmented research publish 3.02 times more papers, receive 4.84 times more citations and become research project leaders 1.37 years earlier than those who do not. By contrast, AI adoption shrinks the collective volume of scientific topics studied by 4.63% and decreases scientists’ engagement with one another by 22%. By consequence, adoption of AI in science presents what seems to be a paradox: an expansion of individual scientists’ impact but a contraction in collective science’s reach, as AI-augmented work moves collectively towards areas richest in data. With reduced follow-on engagement, AI tools seem to automate established fields rather than explore new ones, highlighting a tension between personal advancement and collective scientific progress.
Generative AI Meets Open-Ended Survey Responses: Research Participant Use of AI and Homogenization
The growing popularity of generative artificial intelligence (AI) tools presents new challenges for data quality in online surveys and experiments. This study examines participants’ use of large language models to answer open-ended survey questions and describes empirical tendencies in human versus large language model (LLM)-generated text responses. In an original survey of research participants recruited from a popular online platform for sourcing social science research subjects, 34 percent reported using LLMs to help them answer open-ended survey questions. Simulations comparing human-written responses from three pre-ChatGPT studies with LLM-generated text reveal that LLM responses are more homogeneous and positive, particularly when they describe social groups in sensitive questions. These homogenization patterns may mask important underlying social variation in attitudes and beliefs among human subjects, raising concerns about data validity. Our findings shed light on the scope and potential consequences of participants’ LLM use in online research.
How LLMs Distort Our Written Language
Large language models (LLMs) are used by over a billion people globally, most often to assist with writing. In this work, we demonstrate that LLMs not only alter the voice and tone of human writing but also consistently alter the intended meaning. First, we conduct a human user study to understand how people actually interact with LLMs when using them for writing. Our findings reveal that extensive LLM use led to a nearly 70% increase in essays that remained neutral in answering the topic question. Significantly more heavy LLM users reported that the writing was less creative and not in their voice. Next, using a dataset of human-written essays that was collected in 2021 before the widespread release of LLMs, we study how asking an LLM to revise the essay based on the human-written feedback in the dataset induces large changes in the resulting content and meaning. We find that even when LLMs are prompted with expert feedback and asked to only make grammar edits, they still change the text in a way that significantly alters its semantic meaning. We then examine LLM-generated text in the wild, specifically focusing on the 21% of AI-generated scientific peer reviews at a recent top AI conference. We find that LLM-generated reviews place significantly less weight on clarity and significance of the research, and assign scores that, on average, are a full point higher. These findings highlight a misalignment between the perceived benefit of AI use and an implicit, consistent effect on the semantics of human writing, motivating future work on how widespread AI writing will affect our cultural and scientific institutions.
How LLMs Distort Our Written Language
Large language models (LLMs) are used by over a billion people globally, most often to assist with writing. In this work, we demonstrate that LLMs not only alter the voice and tone of human writing but also consistently alter the intended meaning. First, we conduct a human user study to understand how people actually interact with LLMs when using them for writing. Our findings reveal that extensive LLM use led to a nearly 70% increase in essays that remained neutral in answering the topic question. Significantly more heavy LLM users reported that the writing was less creative and not in their voice. Next, using a dataset of human-written essays that was collected in 2021 before the widespread release of LLMs, we study how asking an LLM to revise the essay based on the human-written feedback in the dataset induces large changes in the resulting content and meaning. We find that even when LLMs are prompted with expert feedback and asked to only make grammar edits, they still change the text in a way that significantly alters its semantic meaning. We then examine LLM-generated text in the wild, specifically focusing on the 21% of AI-generated scientific peer reviews at a recent top AI conference. We find that LLM-generated reviews place significantly less weight on clarity and significance of the research, and assign scores that, on average, are a full point higher. These findings highlight a misalignment between the perceived benefit of AI use and an implicit, consistent effect on the semantics of human writing, motivating future work on how widespread AI writing will affect our cultural and scientific institutions.
Towards End-to-End Automation of AI Research
The automation of science is a long-standing ambition in the field of AI. While the community has made significant progress in automating individual components of the scientific process, a system that autonomously navigates the entire research lifecycle -- from conception to publication -- has remained out of reach. Here, we present the strongest demonstration to date toward automating the entire process end-to-end. We present The AI Scientist, which creates research ideas, writes code, runs experiments, plots and analyzes data, writes the entire scientific manuscript and performs its own peer review. Its ideas, execution, and presentation are of sufficient quality to produce a manuscript generated by an AI system that passes the first round of peer review at a major machine learning conference workshop. The workshop has an acceptance rate of 70 percent. Our system leverages modern foundation models within a complex agentic system. We evaluate The AI Scientist in two settings: a focused mode using human-provided code templates as an initial scaffold to conduct research on a specific topic, and a template-free, open-ended mode that leverages agentic search for wider scientific exploration. Both settings produce diverse ideas and automatically test, report on, and evaluate them. This achievement demonstrates AI's growing capacity for scientific contribution and signifies a potential paradigm shift in how research is conducted. As with any impactful new technology, there could be significant risks, including taxing overwhelmed review systems and adding noise to scientific literature. However, if developed responsibly, such autonomous systems could greatly accelerate scientific discovery.
GIANTS: Generative Insight Anticipation from Scientific Literature
A 17k-example benchmark and RL-trained 4B model for literature-grounded insight anticipation.
