







Exploring critical, philosophical, and scientific debates in psychiatric practice and the psy-sciences. Click to read Psychiatry at the Margins, by Awais Aftab, a Substack publication with tens of thousands of subscribers.
Who Gets to Define Human Suffering?
As psychiatry concedes long-standing criticisms of diagnosis, a deeper question emerges: What now justifies its authority over human suffering?

Computational Psychiatry Needs Systems Neuroscience
This piece was originally published in The Transmitter. I am adapting it here with some additional context for readers of this newsletter.

Pluralistic: Three more AI psychoses (12 Mar 2026) – Pluralistic: Daily links from Cory Doctorow
"AI psychosis" is one of those terms that is incredibly useful and also almost certainly going to be deprecated in smart circles in short order because it is: a) useful; b) easily colloquialized to describe related phenomena; and c) adjacent to medical issues, and there's a group of people who feel very strongly any metaphor that implicates human health is intrinsically stigmatizing and must be replaced with an awkward, lengthy phrase that no one can remember and only insiders understand.
Madness and Enterprise: Psychiatry, Economic Reason, and the Emergence of Pathological Value
Uncovers a powerful relationship between pathology and money: beginning in the nineteenth century, the severity of mental illness was measured against a patient’s economic productivity. Madness and Enterprise reveals the economic norms embedded within psychiatric thinking about mental illness in the North Atlantic world. Over the course of the nineteenth century, various forms of madness were subjected to a style of psychiatric reasoning that was preoccupied with money. Psychiatrists across Western Europe and the United States attributed financial and even moral value to an array of pathological conditions, such that some mental disorders were seen as financial assets and others as economic liabilities. By turning to economic conduct and asking whether potential patients appeared capable of managing their financial affairs or even generating wealth, psychiatrists could often bypass diagnostic uncertainties about a person’s mental state. Through an exploration of the intertwined histories of psychiatry and economic thought, Nima Bassiri shows how this relationship transformed the very idea of value in the modern North Atlantic, as the most common forms of social valuation—moral value, medical value, and economic value—were rendered equivalent and interchangeable. If what was good and what was healthy were increasingly conflated with what was remunerative (and vice versa), then a conceptual space opened through which madness itself could be converted into an economic form and subsequently redeemed—and even revered.

Introducing The Psyche Network
Occurrence of Psychosis and Bipolar Disorder in Individuals With ADHD Treated With Stimulants
This systematic review and meta-analysis evaluates the association between psychosis or bipolar disorder and stimulant treatment among individuals with attention-deficit/hyperactivity disorder.

Leading Innovation in Psychiatric Treatment | Alto Neuroscience
We leverage brain biology to develop personalized medicines, helping patients get better faster.

#1292 Nima Bassiri: Capitalism, Psychiatry, and the Emergence of Pathological Value
AI for Proactive Mental Health: A Longitudinal, Multi-Institutional Trial
Young adults today face unprecedented mental health challenges, yet many hesitate to seek support due to barriers such as accessibility, stigma, and time constr
Why Psychology Hasn’t Had a Big New Idea in Decades
Can our field get its act together?

Retraction Note: The complex lived experience of schizophrenia diagnosis: a thematic analysis of online forum posts
Current Psychology -

Has anyone looked at this paper more closely? I've seen many of my bachelor students refer to it when it comes to depressive disorders. Authors find worldwide depression rates doubled from 1990 to 2020, which seems like a lot. pubmed.ncbi.nlm.nih.gov/40313474/
Trends in Prevalent Cases and Disability-Adjusted Life-Years of Depressive Disorders Worldwide: Findings From the Global Burden of Disease Study From 1990 to 2021 - PubMed
pubmed.ncbi.nlm.nih.gov"[PSH] asks not only what the psychopathic profile is, but where it wins. ... whether the traits that once had to remain parasitic at the margins of reciprocal communities can become structurally amplified in environments where consequence is abstracted and reward is symbolic."
The Psychopathic Selection Hypothesis Guide for Readers
gregelliott2000.substack.comDysthymia

Autistic Burnout vs. Depression | Neurodivergent Insights

Defining autistic burnout through experts by lived experience: Grounded Delphi method investigating #AutisticBurnout - Julianne M Higgins, Samuel RC Arnold, Janelle Weise, Elizabeth Pellicano, Julian N Trollor, 2021

What Is Autistic Burnout? A Thematic Analysis of Posts on Two Online Platforms - Jane Mantzalas, Amanda L. Richdale, Achini Adikari, Jennifer Lowe, Cheryl Dissanayake, 2022

“Having All of Your Internal Resources Exhausted Beyond Measure and Being Left with No Clean-Up Crew”: Defining Autistic Burnout - Dora M. Raymaker, Alan R. Teo, Nicole A. Steckler, Brandy Lentz, Mirah Scharer, Austin Delos Santos, Steven K. Kapp, Morrigan Hunter, Andee Joyce, Christina Nicolaidis, 2020

“Shutdowns Are Like You’re Stuck on the Blue Screen of Death”: A Metaphor Analysis of Autistic Shutdowns - Katie Paris, Alexandru “Zeph” Lodestone, Melissa Houser, Laura Foran Lewis, 2025

Science flags paper that found AI chatbots help debunk conspiracy theories

We Need to Know More About How AI is Affecting Mental Health

Evaluation of Large Language Model Chatbot Responses to Psychotic Prompts

ChatGPT's free version is 26 times more likely to respond inappropriately to psychotic delusions

ChatGPT Has ‘Goblin’ Mania in the US. In China It Will ‘Catch You Steadily’

"AI Psychosis" in Context: How Conversation History Shapes LLM Responses to Delusional Beliefs