Researchers found evidence that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases.
When We Eat, or Don’t Eat, May Be Critical for Health (Published 2018)
A growing body of research suggests that our bodies function optimally when we align our eating patterns with our circadian rhythms.
The Best Exercise for Aging Muscles (Published 2017)
Certain kinds of exercise may mitigate the effects of aging at the cellular level.
Abolishing Daylight Saving Time is easy, setting a permanent time is not
Daylight Saving Time – the biannual ritual of adjusting clocks forwards and backwards – has long been debated. Advocates argue it saves energy and promotes outdoor activities, while critics highlight its disruptive effects on health, productivity, and social routines. This column examines the health impacts, societal costs, and the outdated rationale behind the implementation of Daylight Saving Time, and argues that there is good reason to abolish it. This would imply trade-offs, however. While adopting Standard Time permanently would be better from a health perspective, ‘summer time’ is preferred in many countries.
Montmorency tart cherry protects against age-related bone loss in female C57BL/6 mice and demonstrates some anabolic effects
Age-related bone loss is a consequence of endocrine and immune changes that disrupt bone remodeling. Functional foods (e.g., tart cherries) with antioxidant, anti-inflammatory and prebiotic activity can potentially counter this age-related phenomenon. The aim of this study was to determine if Montmorency tart cherry protects against early age-related bone loss and the culpable alterations in bone metabolism.
Interactions between gut microbiota and skeletal muscle
The gut microbiota is now recognized as a major contributor to the host’s nutrition, metabolism, immunity, and neurological functions. Imbalanced microbiota (ie, dysbiosis) is linked to undernutrition-induced stunting, inflammatory and metabolic diseases, and cancers. Skeletal muscle also takes part in the interorgan crosstalk regulating substrate metabolism, immunity, and health. Here, we review the reciprocal influence of gut microbiota and skeletal muscle in relation to juvenile growth, performance, aging, and chronic diseases. Several routes involving the vascular system and organs such as the liver and adipose tissue connect the gut microbiota and skeletal muscle, with effects on fitness and health. Therapeutic perspectives arise from the health benefits observed with changes in gut microbiota and muscle activity, further encouraging multimodal therapeutic strategies.
Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing
Bone remodeling is the continuous process of bone resorption by osteoclasts and bone formation by osteoblasts, in order to maintain homeostasis. The activity of osteoclasts and osteoblasts is regulated by a network of signaling pathways, including Wnt, parathyroid hormone (PTH), RANKL/OPG and TGF-β, in response to stimuli such as mechanical loading. During aging there is a gradual loss of bone mass due to dysregulation of signaling pathways. This may be due to a decline in physical activity with age and/or changes in hormones and other signaling molecules. In particular, hormones such as PTH have a circadian rhythm which may be disrupted in aging. Due to the complexity of the molecular and cellular networks involved in bone remodeling, several mathematical models have been proposed to aid understanding of the processes involved. However, to date there are no models which explicitly consider the effects of mechanical loading, the circadian rhythm of PTH and the dynamics of signaling molecules on bone remodeling. Therefore, we have constructed a network model of the system using a modular approach which will allow further modifications as required in future research. The model was used to simulate the effects of mechanical loading and also the effects of different interventions such as continuous or intermittent administration of PTH. Our model predicts that the absence of regular mechanical loading and/or an impaired PTH circadian rhythm leads to a gradual decrease in bone mass over time which can be restored by simulated interventions and that the effectiveness of some interventions may depend on their timing.
Mitochondrial Signaling and Stress Responses, Key Regulators of Aging and Longevity
ABSTRACT Mitochondria are vital not only for energy production but also for regulating signaling pathways that influence aging. While mitochondrial dysfunction contributes to age‐related decline, emerging evidence shows that mild, regulated mitochondrial stress can paradoxically promote longevity. This review highlights recent advances in mitochondrial biology and aging across species. We explore the dual role of reactive oxygen species (ROS) as both damaging agents and signaling molecules that activate adaptive stress responses. Key pathways such as the mitochondrial unfolded protein response (UPR MT ) and integrated stress response (ISR) are discussed, including their tissue‐specific as well as non‐cell‐autonomous effects on aging. Additionally, we examine the impact of mitochondrial protein import/export, dynamics (fission, fusion, mitophagy, biogenesis), and quality control in aging. Finally, we address challenges in understanding context‐dependent mitochondrial responses and mitonuclear communication. Together, these insights position mitochondria as central regulators of aging and highlight their potential as therapeutic targets to enhance health span and longevity.
Why working fewer hours would make us more productive
A shorter working week could improve our mental and physical health and even mitigate climate change, research shows
Nikhil Krishnan on Twitter / X
yeah there used to be a company called Eureka that powered these types of observational, more lifestyle style studies (here's an example looking at coffee's effect on different biomarkers/conditions)https://t.co/urQRvTVTb7I think it can work if you have enough people in…— Nikhil Krishnan (@nikillinit) September 14, 2025
Low on energy? A new understanding of rest could help revitalise you
There is a state of relaxation that few of us spend much time in, but which comes with profound well-being benefits. With healthier ageing, reduced risk of disease and feeling more energised all on offer, here's how to get there
Chronic methylphenidate abuse: Effects on behaviour, redox homeostasis, and cholinergic system
Methylphenidate (MPH) (metil 2-fenil-2-(piperidin-2-il) acetato) is used as a drug of abuse as well as a cognitive enhancer owing to its amphetaminic structure. The objective of this study was to evaluate whether chronic exposure to an abusive context and dose of MPH (80 mg/L for 15 min/day for 7 days) in adult life causes behavioural changes related to anxiety, fear, sociability, locomotion, and memory as well as altered levels of biochemical markers, cortisol, and the cholinergic system. Here we used the zebrafish (Danio rerio) as a translatio Nnal model. We showed that fish exposed to MPH showed marked hypolocomotion and anxiogenic patterns, fear behaviour, and memory delay. MPH exposure also increased the levels of antioxidant enzymes, non-protein thiols, and reactive oxygen species compared with those in the control group, and the redox status was altered at the cerebral and peripheral levels. The cholinergic system exhibits a reduction in signalling and an increase in cortisol levels. Our results clarified the mechanisms involved in the toxicity elicited by the abusive use of MPH. Overall, our results demonstrated that chronic administration of an abusive dose of MPH in individuals without a diagnosis of attention deficit hyperactivity disorder (ADHD) can cause important damage.
Brett Scott (@brettscott)
Despite all the rhetoric about automation supposedly making our lives easier, the true story being told by Big Tech is that our lives are better when speeded up You are supposed to be in an ever-accelerating race, packing more units of experience into the same unit of time, a phenomenon that requires a contraction of patience and a blurring of experience as everything quickens In the end, this is what ‘convenience’ actually is. It’s a state of being in which you become disassociated and disengaged from the texture of the world around you. You pass through it dreamlike, and suddenly wake up decades years later as an elderly person on your deathbed, thinking “WTF happened”, as then the memory slips away
#paperclip | James Zou | 46 comments
What if, for any scientific claim, you can search 100M+ papers to find the strongest evidence for and against it ⚡️ in 1 second? That’s now possible with Evidence API! 🚀 https://lnkd.in/dzQ_HT-P Evidence API combines #paperclip with our new Jev-style model trained to extract relevant evidence in lightning speed. Great job by Kevin Wu and GXL For example, does drinking coffee reduce diabetes risk? | 46 comments on LinkedIn
Sleep as a Competitive Advantage
Too many of us live by the myth that one less hour of sleep gives us one more hour of productivity, Tony Schwartz writes in the Life@Work column. In reality, lost sleep not only leaves us more fatigued, but also takes a toll on our cognitive capacity.
Does engaging with the arts help to slow the aging process? According to this new paper from Fancourt et al the answer is yes! Alas, the paper is actually unsuitable for such claims. Let’s examine by discussing how you'd establish whether arts engagement actually caused future health! 1/18 🧵
Does leisure activity matter for epigenetic ageing? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study
academic.oup.com