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The Second Brain That Grows Smarter and Lives on your Computer

How a spark from Andrej Karpathy, app called Obsidian, and “The Curator”, the app I built are changing the way I think.

Tolaria

A second brain for the AI era. Free forever, local-first, Markdown-based, Git-ready, and AI-friendly.

Brainchildren

Minds are complex artifacts, partly biological and partly social; only a unified, multidisciplinary approach will yield a realistic theory of how they came i...

Introducing TRIBE v2: AI Model Predicts Human Brain Responses | AI at Meta posted on the topic | LinkedIn

Today we're introducing TRIBE v2, a foundation model trained to predict how the human brain responds to almost any sight or sound. Building on our Algonauts 2025 award-winning architecture, TRIBE v2 draws on 500+ hours of fMRI recordings from 700+ people to create a digital twin of neural activity. It enables zero-shot predictions for new subjects, languages, and tasks, consistently outperforming standard modeling approaches. We’re releasing the model, codebase, paper, and an interactive demo to help researchers advance neuroscience, apply brain insights to build better AI, and use computational simulation to speed up breakthroughs in neurological disease diagnosis and treatment. Try the demo and learn more here: https://go.meta.me/tribe2 | 175 comments on LinkedIn

Introducing TRIBE v2: A Predictive Foundation Model Trained to Understand How the Human Brain Processes Complex Stimuli

Understanding how the human brain processes the world around us is one of the greatest open challenges in neuroscience. Breakthroughs here could transform how we understand and treat neurological conditions affecting hundreds of millions of people — and improve AI systems by directly guiding their development from neuroscientific principles.

Introducing TRIBE v2: A Predictive Foundation Model Trained to Understand How the Human Brain Processes Complex Stimuli | Keith Doelling

This is some very cool work by some awesome colleagues Jean-Rémi King, and Teon Brooks! Seriously not enough good things can be said about how cool it is. You should enjoy it and play with it. And kudos to Meta for open sourcing it. At the same time, I'm already seeing posts about how the model will replace fMRI experiments as researchers will simulate how the brain "really works" instead of running costly experiments. I think this goes WELL beyond what its creators intend. We are already seeing that use of AI in science allows you to explore charted ideas more thoroughly and much more rapidly but slows us down in finding novel ideas (https://lnkd.in/eMR2akqt). At the same time, there is growing concern that LLM performance will collapse as they are increasingly trained on their own output (https://lnkd.in/eavgfyuY). Leaving neuroscience to AI simulations risks following the same fate, where we generate seemingly new findings without gaining new meaning. A mechanistic understanding of how the brain works (if that is still your goal) will be found at the margins, in errors and idiosyncrasies of neural function. What TRIBE provides is a super useful and cool instantiation of our current understanding on how and where neural activity is instantiated in the brain. But it won't help us make groundbreaking new findings of how neural circuits lead to cognition and behavior. Experiments on real human brains, may be costly, but they will always be necessary!

Introducing TRIBE v2: A Predictive Foundation Model Trained to Understand How the Human Brain Processes Complex Stimuli | Keith Doelling

This is some very cool work by some awesome colleagues Jean-Rémi King, and Teon Brooks! Seriously not enough good things can be said about how cool it is. You should enjoy it and play with it. And kudos to Meta for open sourcing it. At the same time, I'm already seeing posts about how the model will replace fMRI experiments as researchers will simulate how the brain "really works" instead of running costly experiments. I think this goes WELL beyond what its creators intend. We are already seeing that use of AI in science allows you to explore charted ideas more thoroughly and much more rapidly but slows us down in finding novel ideas (https://lnkd.in/eMR2akqt). At the same time, there is growing concern that LLM performance will collapse as they are increasingly trained on their own output (https://lnkd.in/eavgfyuY). Leaving neuroscience to AI simulations risks following the same fate, where we generate seemingly new findings without gaining new meaning. A mechanistic understanding of how the brain works (if that is still your goal) will be found at the margins, in errors and idiosyncrasies of neural function. What TRIBE provides is a super useful and cool instantiation of our current understanding on how and where neural activity is instantiated in the brain. But it won't help us make groundbreaking new findings of how neural circuits lead to cognition and behavior. Experiments on real human brains, may be costly, but they will always be necessary!

Memorize details from AI research papers

The second brain of AI researchers for machine learning, computer vision and natural language processing paper reviews.

The Entangled Brain: How Perception, Cognition, and Emotion Are Woven Together

A new vision of the brain as a fully integrated, networked organ.Popular neuroscience accounts often focus on specific mind-brain aspects like addiction, c

To Make Sense of the Present, Brains May Predict the Future | Quanta Magazine

A controversial theory suggests that perception, motor control, memory and other brain functions all depend on comparisons between ongoing actual experiences and the brain’s modeled expectations.

Obsidian AI Second Brain: The Free Self-Organizing Plugin | Agrici Daniel

claude-obsidian turns Obsidian into a self-organizing AI second brain. 15 skills, v1.9 Compound Vault, plain Markdown you own. MIT licensed, zero manual filing.

The brain in the machine: How AI could help explain how we think | IBM

Scientists are using large AI models to predict patterns of brain activity at scale, a development that researchers say is pushing neuroscience toward a new kind of digital imaging.

The Many Brains Project

The Many brains project

Plastic Labs Releases Neuromancer XR

NEUROMANCER: The first collection of models dedicated to AI-native memory and social cognition.

Embracing the suboptimal organization of the human brain

Human brain architecture is guiding brain-inspired artificial intelligence (AI) and has been treated as an optimal template, whose deviations could mark different psychiatric and neurological conditions. We argue this premise is wrong: under any single goal (e.g., minimal wiring cost or maximal communication efficiency), the human connectome is suboptimal. Instead, its organization reflects multi-objective trade-offs navigated over evolution and development under biological and environmental constraints. For psychopathology, atypical trajectories are not distances from an ideal brain but reweighted compromises in the same trade-off space. For neuro-AI, directly duplicating the brain’s connectivity risks copying its irrelevant compromises. Treating brains and models as products of multi-objective optimization and co-tuning relevant objectives offers a more powerful framework for interpreting clinical phenotypes and designing next-generation AI.