







Book 1: The Basic Straining Manual -- Book 2: The Delphi Coracle -- Book 3: Splicing the Brain Race
The Cognitive Debt of Digging Through Preprints
Your Brain on MIT Media Lab

Homepage — PL Neuro
David A. Markowitz, Juan Benet, Jacques Carolan, Eli Dourado, Thomas Kalil, Amy Kruse, Adam Marblestone, Patrick Mineault, Joanne Peng, Joshua Rosenow, Sean Escola

Computational Psychiatry Needs Systems Neuroscience
This piece was originally published in The Transmitter. I am adapting it here with some additional context for readers of this newsletter.

This Is Your Brain on Podcasts (Published 2016)
Different people’s brains absorb a compelling story in the roughly the same complicated pattern, using many parts of the brain, researchers found.

The Divided Brain (2019) | How the Left Brain Hijacked the Modern World
Open-source software reveals complete 3D architecture of brain cells
The neurons in our brain that underlie thought connect to each other using tiny branch-like structures on their surfaces known as dendritic spines. Now scientists at Columbia's Zuckerman Institute and ...

A running list of ATproto ideas - Tynan's Leaflets
Updated when the brain has more
The New Wounded
This book addresses the issue of trauma and psychic wounds to stage a confrontation between psychoanalysis and contemporary neurobiology. In so doing, it reevaluates the brain as an organ that is not separated from psychic life but rather appears as its very locus. A philosophical approach of the “new wounded” (brain lesion patients) forms the matter of the confrontation.

Building a Second Brain: The Definitive Introductory Guide
This is an introduction to Building a Second Brain, the proven method to organize your digital life and unlock your creative potential

Ultra-Processed Minds: The End of Deep Reading and What It Costs Us
A reflection on the reading life. What formed it, what threatens it, and what remains.

Neuralink and the Brain's Magical Future — Wait But Why
I knew the future would be shocking but this is a whole other level.

Another valuable AI tool to address the massive de-skilling event we are currently experiencing! By @lav.io
Sam Lavigne
I made a chrome extension that makes LLMs appear to run very slowly... slowllm.lav.io
1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social biorxiv.org/content/10.1101/2025.11.12.68…
Characterizing neuronal population geometry with AI equation discovery
www.biorxiv.org
The Many Brains Project
Project Overview ‹ NeuroDatasets Tool – MIT Media Lab

E11 Bio | Moonshot Neuroscience
Conduit

Dandelion Science — from digital brains to therapies

Fluent BCI | Intelligence over Invasiveness

Danilo Bzdok | Mila

Neuroscience needs a career path for software engineers

Neuro-RSE Affinity Group
andrewheusser.github.io

About Patrick Mineault
Phillip M. Alday

Anti-democratic attitudes are highly contagious, new psychology study finds
Hyperactive–impulsive ADHD traits predict higher curiosity in adults: evidence from a cross-sectional study
Understanding the influence of digital technology on human cognitive functions: A narrative review

How the hypercuriosity of ADHD may have helped humans thrive | Aeon Essays

The Entangled Brain: How Perception, Cognition, and Emotion Are Woven Together