Claude Science (beta)

Claude Science is your AI workbench for scientific research. Works through your research like a skilled scientist, running the analysis and tracing every step. Spend less time stitching pipelines together, and more time on the science.

Lacuna: A Research Map for Machine Learning

Lacuna is a research map for machine learning that uses LLMs to turn papers and scholarly metadata into markdown summaries, concept elements, research directions, and research proposals. Each item keeps links to the primary source records and papers that support it. We release the map with web, markdown, and MCP interfaces. Across LitSearch, Multi-XScience-CS/ML, and ScholarQA-CS-ML, Lacuna outperforms OpenScholar with the strongest gains on LitSearch retrieval (Recall@10 0.538 vs. 0.424 for OpenScholar v3). We also evaluate Lacuna Deep Research, a multi-stage report agent over the map, on 25 ReportBench-ML survey tasks: Lacuna Deep Research reaches 0.052 citation F1, 0.339 citation precision, 99 expert-reference hits, and 7.82/10 RACE report quality, while GPT-Researcher reaches 0.039 F1, 0.290 precision, 72 hits, and 5.24/10 RACE.

Agentic Laboratories of the Future: Towards World Models for Scientific Discovery

Scientific discovery is fundamentally a problem-solving process involving distributed intelligence. Human intuition, computational reasoning, and experimental execution are distributed across people, instruments, and software systems, limiting the speed and scale of discovery. Although automation, high-throughput experimentation, foundation models, and cloud infrastructure have accelerated individual stages of the scientific workflow, they have not unified the discovery process. We hypothesize that the next generation of laboratories will be agentic: environments in which scientists, AI systems, and robotic platforms operate as collaborative discovery partners, with humans contributing the parts of discovery that remain hardest to make explicit: asking the right questions and holding provisional mechanistic models of how a system works. The key missing layer is an agentic harnessing layer that continuously integrates hypothesis, literature-derived evidence, experimental data, uncertainty, and experimental state into a shared “laboratory world model”—a dynamic representation of the scientific system and its evolving context. By maintaining and updating this lab world model, the agentic harnessing layer enables coordinated decision-making, adaptive planning, and increasingly autonomous scientific workflows across humans and machines. A central challenge is that much of the scientific research process remains inaccessible to machines, including tacit knowledge, human observations, adaptive decision-making, and evolving experimental context. Advances in multimodal AI and immersive interfaces may help bridge this gap, allowing humans, agents, and robotic systems to collaborate seamlessly in scientific discovery rather than simply automating isolated tasks. Agentic laboratories could provide a new architecture for science, integrating human, artificial, and physical intelligence into a unified discovery system.

Early science acceleration experiments with GPT-5

AI models like GPT-5 are an increasingly valuable tool for scientists, but many remain unaware of the capabilities of frontier AI. We present a collection of short case studies in which GPT-5 produced new, concrete steps in ongoing research across mathematics, physics, astronomy, computer science, biology, and materials science. In these examples, the authors highlight how AI accelerated their work, and where it fell short; where expert time was saved, and where human input was still key. We document the interactions of the human authors with GPT-5, as guiding examples of fruitful collaboration with AI. Of note, this paper includes four new results in mathematics (carefully verified by the human authors), underscoring how GPT-5 can help human mathematicians settle previously unsolved problems. These contributions are modest in scope but profound in implication, given the rate at which frontier AI is progressing.

Reimagining research papers as interactive and reliable AI agents

Here we introduce Paper2Agent, an automated framework that converts research papers into artificial intelligence (AI) agents. Paper2Agent transforms research output from passive artefacts into active systems that accelerate use and discovery. Conventional research papers require readers to understand and adapt the paper’s code, data and methods to their work, creating barriers to dissemination and reuse. Paper2Agent addresses this challenge by converting a paper into an AI agent that functions as a virtual corresponding author, exposing its manuscript, supplementary materials, datasets, code and workflows as active, agent-native knowledge rather than static text. It analyses the paper and codebase using multiple agents to construct a model context protocol (MCP) server, then generates and runs tests to refine and increase robustness of the MCP. These paper MCPs can be connected to a chat agent (such as Claude Code) to carry out complex scientific queries through natural language while invoking tools and workflows from the paper. We demonstrate Paper2Agent’s effectiveness through case studies. Paper2Agent created an agent that leveraged AlphaGenome1 to interpret genomic variants and agents based on Scanpy2 and TISSUE (transcript imputation with spatial single-cell uncertainty estimation)3 to conduct single-cell and spatial transcriptomics analyses. We validate that these agents reproduce the results of the original papers and carry out novel user queries. Paper2Agent created multiple agents that collaborate to prioritize a causal gene for psoriasis. By turning static papers into interactive AI agents, Paper2Agent introduces a paradigm for knowledge dissemination and a collaborative ecosystem of AI co-scientists.

The Alien Space of Science: Sampling Coherent but Cognitively...

Scientific discovery is constrained not only by what is true, but by what is cognitively available to the researchers currently exploring a field. Many directions are coherent in light of the...

NovGauge: A Fine-Grained Benchmark for Diagnosing LLMs'...

Large language models (LLMs) are increasingly used in peer review at major AI conferences, yet novelty remains a persistent weak point. Existing benchmarks assess novelty as a single holistic...

Citing Less Critically: LLMs Reshape the Rhetoric and Reach of Scientific Citation

Scientific citations carry rhetorical intent. Scholars may cite prior work positively (supporting), negatively (contrasting), or neutrally (mentioning). As large language models (LLMs) increasingly assist scientific writing, whether they reproduce citations with the same rhetorical intent as humans remains unclear. We introduce a masked-citation task to compare human and LLM-generated citation behavior. For each citation context, an LLM generates a replacement citation sentence, producing a counterfactual corpus directly comparable to human citation. We analyze what, whom, and how models cite, using an LLM-as-a-judge to classify citation intent and a 20-million-edge coauthorship network to measure social distance between cited authors. Across six popular LLMs and 1,746 top NLP conference papers (63k+ contexts, 132k+ citations), three patterns emerge: (1) Compared with human citation, LLMs cite significantly less critically; (2) LLMs over-cite popular and older papers, a tendency amplified for contrasting citations where human writing more often draws on recent, niche work; (3) Whereas humans often cite within their close social network, especially for supporting citations, LLMs tend to draw on more socially distant authors. Together, these differences are double-edged: LLM citation reaches beyond a scholar's close collaborators while being less critical and amplifying visibility bias, reshaping the rhetoric and reach of scientific citation.

Arvind Narayanan on Twitter / X

This week I had the honor of speaking to Princeton’s entire incoming undergraduate class to address their AI anxieties. I had three messages for them — good news, bad news, and a note of optimism. Here’s a condensed version.The good newsWe have enough evidence now to conclude…— Arvind Narayanan (@random_walker) August 27, 2026

AI Research Evaluation: Negative Findings and Failure Modes | Arvind Narayanan posted on the topic | LinkedIn

📢AI agents can autonomously conduct AI research when the result is easily verifiable, but what about open-ended AI research? That’s much harder to study, and our new preprint is our first crack at doing so. Our main finding is negative, and we identify five recurring failure modes. https://lnkd.in/eGKYi4Sa Our results are tentative, and we are working to address the limitations (sample size, potential scaffold improvements). But if the finding holds up, what are the implications? It depends on whether you think recursive self improvement can be achieved simply by hill climbing at scale (I personally don’t think so) and whether you think current limitations of open-ended research like judgment and creativity could change quickly (I’m personally very open to this possibility). We plan to continue this style of evaluation — which we call shadow evaluation — on a regular basis. We’ve wanted to do this for two years, but it took so long because we wanted to get the method right. The idea behind shadow evaluation was suggested by some of the UK AISI coauthors of the paper and refined by the Princeton team. This method has important advantages (and limitations) over the current ways of evaluating agents’ ability to conduct AI research. If you’re an AI researcher interested in working with us on a shadow evaluation based on one of your papers, we’d love to hear from you. https://lnkd.in/ecyp55SW This type of evaluation necessarily involves a ton of researcher flexibility in design, execution, and interpretation. Members of the core team have a particular position in the debate on recursive self-improvement / superintelligence, and this could influence how we conduct the research. We have a detailed section in the paper on our potential biases and how we address them. We sought out a team of collaborators who don’t all share our priors, and we explicitly surface the interpretive disagreements that resulted. For future evaluations, we are interested in having “adversarial collaborators” as part of the core team. This paper exists because of the careful, time-consuming and very much human work that Peter Kirgis, Sayash Kapoor, Andrew Schwartz, and Stephan Rabanser did over the last few months. I’m also very grateful to the larger group of collaborators and co-authors. The work is part of the larger CRUX project that pushes frontier AI agents beyond what benchmarks can measure (https://cruxevals.com/). We are looking for a senior researcher to join the team: https://lnkd.in/e9dC22X5

Leiden Declaration on Artificial Intelligence and Mathematics

This declaration calls for action to address the challenges posed by the use of artificial intelligence within mathematics research.

Can AI agents conduct open-ended AI research? Early evidence from two case studies

Forecasts of explosive AI progress hinge on AI agents automating AI research. But evidence on whether agents can carry out open-ended AI research is thin. Current evaluations either test agents on narrow, verifiable tasks, which excludes open-ended research, or submit AI-generated papers to blind peer review, which is overstretched, stochastic, and suffers from poor review quality. We introduce a third way to measure progress towards AI R\&D automation. An agent takes on the central, open-ended research question of a high-quality unpublished paper, and the paper's original authors grade its output. We call these shadow evaluations. We ran shadow evaluations on two unpublished NeurIPS 2026 submissions, giving frontier agents six days and thousands of dollars of compute. The agents completed all of the engineering without human help, yet could not make substantial progress towards answering the research questions. As a result, both papers were unambiguously rejected by the authors. We identify five recurring failure modes: poor judgment about the bar for publishable research, uncreative responses to shortcomings in the research design, ineffective backtracking from dead ends, poor resource awareness, and instruction drift. A robustness check with a second model and scaffold reproduced these failures. We release the expert reviews, survey responses, agent repositories, and logs. Our results provide early evidence that today's agents can do the engineering of AI research, but struggle with critical parts of the research lifecycle.

RRGI · Discourse Graph — lens switch

The diffusion of large language models in published academic articles | PNAS

Large language models (LLMs) are rapidly changing academic research, raising questions of who is adopting these tools and under what conditions. Th...

An OpenAI model has disproved a central conjecture in discrete geometry

An OpenAI model solved the 80-year-old unit distance problem, disproving a major conjecture in discrete geometry and marking a milestone in AI-driven mathematics.

AI Is Changing Who Wins Research Grants

A new study from the Northwestern Innovation Institute finds that proposals showing stronger signs of AI-assisted writing were more likely to receive support from the National Institutes of Health, while also tending to align more closely with ideas that had already been funded.

Mathematical methods and human thought in the age of AI

Artificial intelligence (AI) is the name popularly given to a broad spectrum of computer tools designed to perform increasingly complex cognitive tasks, including many that used to solely be the province of humans. As these tools become exponentially sophisticated and pervasive, the justifications for their rapid development and integration into society are frequently called into question, particularly as they consume finite resources and pose existential risks to the livelihoods of those skilled individuals they appear to replace. In this paper, we consider the rapidly evolving impact of AI to the traditional questions of philosophy with an emphasis on its application in mathematics and on the broader real-world outcomes of its more general use. We assert that artificial intelligence is a natural evolution of human tools developed throughout history to facilitate the creation, organization, and dissemination of ideas, and argue that it is paramount that the development and application of AI remain fundamentally human-centered. With an eye toward innovating solutions to meet human needs, enhancing the human quality of life and expanding the capacity for human thought and understanding, we propose a pathway to integrating AI into our most challenging and intellectually rigorous fields to the benefit of all humankind.

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